521-34-6 Usage
Description
Sciadopitysin, a biflavonoid originally isolated from Ginkgo biloba, is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone. It exhibits a wide range of biological activities, including reducing cytotoxicity, decreasing insulin secretion, and inhibiting various cellular processes.
Uses
Used in Pharmaceutical Applications:
Sciadopitysin is used as a neuroprotective agent for reducing cytotoxicity induced by amyloid-β (1-42) (Aβ42) in PC12 cells. It helps protect neurons from damage caused by this peptide, which is associated with neurodegenerative diseases like Alzheimer's.
Used in Pancreatic Cell Protection:
Sciadopitysin is used as a protective agent for RIN-m5F pancreatic β-cells, where it decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity. This suggests its potential use in managing or treating conditions related to pancreatic β-cell dysfunction.
Used in Multidrug Resistance Modulation:
Sciadopitysin is used as a modulator of P-glycoprotein (P-gp), with an IC50 of 53.42 μM. It increases the cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells, indicating its potential role in overcoming multidrug resistance in cancer treatment.
Used in Bone Health Applications:
Sciadopitysin is used as an inhibitor of RANKL-induced mRNA expression of osteoclast-specific genes CTSK, TRAP, and MMP-9, as well as the activation of NF-κB and osteoclastogenesis in a mouse model of LPS-induced bone loss. This suggests its potential use in treating bone-related disorders and conditions where bone loss is a concern.
Check Digit Verification of cas no
The CAS Registry Mumber 521-34-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 521-34:
(5*5)+(4*2)+(3*1)+(2*3)+(1*4)=46
46 % 10 = 6
So 521-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C33H24O10/c1-39-18-7-4-16(5-8-18)27-15-25(38)32-23(36)13-22(35)30(33(32)43-27)20-10-17(6-9-26(20)41-3)28-14-24(37)31-21(34)11-19(40-2)12-29(31)42-28/h4-15,34-36H,1-3H3
521-34-6Relevant articles and documents
A new strategy for the synthesis of biflavonoids via arylboronic acids
Muller, Dominique,Fleury, Jean-Pierre
, p. 2229 - 2232 (2007/10/02)
Amentoflavone derivatives were prepared by catalytic coupling of 8-flavone-boronic acids with iodoflavones. 3-Arylflavones, as biflavonoid synthon, are accessible by the method.