52178-47-9Relevant articles and documents
Seleno-functionalization of quercetin improves the non-covalent inhibition of mpro and its antiviral activity in cells against sars-cov-2
Mangiavacchi, Francesca,Botwina, Pawel,Menichetti, Elena,Bagnoli, Luana,Rosati, Ornelio,Marini, Francesca,Fonseca, Sérgio F.,Abenante, Laura,Alves, Diego,Dabrowska, Agnieszka,Kula-Pacurar, Anna,Ortega-Alarcon, David,Jimenez-Alesanco, Ana,Ceballos-Laita, Laura,Vega, Sonia,Rizzuti, Bruno,Abian, Olga,Lenard?o, Eder J.,Velazquez-Campoy, Adrian,Pyrc, Krzysztof,Sancineto, Luca,Santi, Claudio
, (2021/07/02)
The development of new antiviral drugs against SARS-CoV-2 is a valuable long-term strategy to protect the global population from the COVID-19 pandemic complementary to the vaccination. Considering this, the viral main protease (Mpro ) is among
Reaction of Areneselenyl Chlorides and alkenes. An example of Nucleophilic Displacement at Bivalent Selenium
Schmid, George H.,Garratt, Dennis G.
, p. 4169 - 4172 (2007/10/02)
The effect of substituents in the phenyl ring of both the electrophile and the alkene has been studied in the reaction of areneselenyl chlorides and (E)- and (Z)-1-phenylpropenes.Electron-donating groups in both phenyl rings enhance the rate of reaction.Viewing this reaction as a nucleophilic displacement at bivalent selenium leads to a model that allows the possibility of reaction by a continuum of mechanisms.These mechanisms differ only in the relative amounts of C-Se bond making and Se-Cl bond breaking in the rate-determining transition state.From our data, it is concluded that C-Se bond making lags behind Se-Cl bond breaking in the rate determining transition state.
