52179-44-9 Usage
Description
Graphislactone A is a significant analogue of phenolic benzopyranones, a class of compounds derived from a mycobiont of lichens belonging to the genus Graphis. It was first identified by Japanese researchers at Kobe Pharmaceutical University in 1997. Graphislactone A is known for its potent antioxidant properties, which enable it to protect against oxidative injury through dose-dependent free radical scavenging and antioxidant activity.
Uses
Used in Pharmaceutical Industry:
Graphislactone A is used as a pharmaceutical agent for its antioxidant properties. It is particularly effective in protecting against oxidative injury, which can lead to various diseases and conditions. Graphislactone A's ability to scavenge free radicals and exhibit antioxidant activity makes it a promising candidate for the development of treatments aimed at reducing oxidative stress and its associated health issues.
Used in Antioxidant Applications:
In the field of antioxidant research and application, Graphislactone A is utilized for its dose-dependent free radical scavenging capabilities. This makes it a valuable component in the development of products designed to combat the harmful effects of oxidative stress, which can contribute to the aging process, chronic diseases, and other health problems.
Used in Cosmetics Industry:
Graphislactone A can also be employed in the cosmetics industry as an ingredient in skincare and beauty products. Its antioxidant properties can help protect the skin from environmental damage, such as exposure to harmful UV rays and pollutants, while also promoting skin health and reducing the visible signs of aging.
Used in Nutraceutical Applications:
In the nutraceutical sector, Graphislactone A can be incorporated into dietary supplements and functional foods to provide consumers with the benefits of its antioxidant properties. This can help support overall health and well-being by reducing oxidative stress and promoting a balanced internal environment.
Check Digit Verification of cas no
The CAS Registry Mumber 52179-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,1,7 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52179-44:
(7*5)+(6*2)+(5*1)+(4*7)+(3*9)+(2*4)+(1*4)=119
119 % 10 = 9
So 52179-44-9 is a valid CAS Registry Number.
52179-44-9Relevant articles and documents
Total synthesis of graphislactones A, C, D, and H, of ulocladol, and of the originally proposed and revised structures of graphislactones e and F
Altemoeller, Martina,Gehring, Timo,Cudaj, Judith,Podlech, Joachim,Goesmann, Helmut,Feldmann, Claus,Rothenberger, Alexander
experimental part, p. 2130 - 2140 (2009/09/29)
Graphislactones A-H and the structurally related ulocladol are highly oxygenated resorcylic lactones produced by lichens and fungi. We present total syntheses of graphislactones A, C-F, H and of ulocladol. Graphislactones E, F, and H were synthesized for the first time. The spectra of graphislactones E and F synthesized as the originally proposed structures were not in agreement with published data. Consequently, revised structures for these compounds are proposed, whose correctness is unambiguously proven by total synthesis and comparison of the spectroscopic data. Key steps in all syntheses are Suzuki couplings for the construction of the central biaryl bond and Dakin reactions to supply further hydroxy groups required in these highly oxygenated substrates. Graphislactones A, C, and H, acylated graphislac- tone D and ulocladol were prepared in 8-11 steps with 7-20% yield starting with purchasable compounds, where the longest linear sequence consists of 5-9 steps. The syntheses are thus significantly shorter than the previously published syntheses of graphislactones A-D and of ulocladol. Graphis- lactones E and F were synthesized in 8 steps, where the longest linear sequences consist of 6 and 5 steps, respectively. They were isolated as the respective acetylated compounds with 25 and 10% yield.
