521915-96-8

Basic information

• Product Name: 2-CHLORO-3-(CHLOROMETHYL)-7-METHYLQUINOLINE
• Synonyms: 2-CHLORO-3-(CHLOROMETHYL)-7-METHYLQUINOLINE;OTAVA-BB 1049505
• CAS NO: 521915-96-8
• Molecular Formula: C₁₁H₉Cl₂N
• Molecular Weight: 226.1
• Mol File: 521915-96-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 348.5°C at 760 mmHg
• Flash Point: 195.4°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 2-CHLORO-3-(CHLOROMETHYL)-7-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-(CHLOROMETHYL)-7-METHYLQUINOLINE(521915-96-8)
• EPA Substance Registry System: 2-CHLORO-3-(CHLOROMETHYL)-7-METHYLQUINOLINE(521915-96-8)

Safety Data

• Hazardous Substances Data: 521915-96-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9Cl2N/c1-7-2-3-8-5-9(6-12)11(13)14-10(8)4-7/h2-5H,6H2,1H3

Upstream product

• 19352-22-8 3-chloro-N-(3-methylphenyl)propionamide 
• 68-12-2 N,N-dimethyl-formamide 
• 68236-21-5 2-chloro-3-formyl-7-methylquinoline 
• 170848-22-3 3-(hydroxymethyl)-2-chloro-7-methylquinoline 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 1350804-26-0 C₂₈H₂₀Cl₂N₂O₂ 

Relevant articles and documents

Quinoline and 2-nitroimino-1, 3-diazacycloalkane hybrids: Design, synthesis and insecticidal activity

A library of new hybrid molecules comprising quinoline, 2-nitroimino-1, 3-diazacycloalkane motifs were designed and synthesized as plausible neonicotinoid analogues. These compounds were synthesized from 2-chloro/aryloxy-3-formyl quinolines and guanidine nitrate with the coupling of 2-chloro/aryloxy-3-(chloromethyl)quinolines, 2-nitroimino-1, 3-diazacycloalkanes under phase transfer catalysis (PTC) as crucial step. All the compounds were obtained in excellent yields (80–90%) and were characterized by 1H, 13C NMR and mass spectrometry. The newly generated compounds were screened for insecticidal activity against aphids in safflower field and some of them displayed moderate activity.

Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents

A new hybrid template designed by linking three pharmacophoric groups, for example, quinoline, triazole and dihydroquinoline moieties have been used for the generation of a library of molecules as potential cytotoxic agents. Synthesis of these polyazaheterocycles were carried out by using a strategy that involved one-pot sequential azidation and CuAAC in water under mild conditions. A number of 1,4-disubstituted 1,2,3-triazoles possessing quinolinylmethylene at N-1 and 1,2-dihydroquinolinyl methylene at C-4 as different substituents were synthesized and evaluated for their cytotoxic effects against various cancer cells. Some of them showed encouraging activities against lung cancer cells and one of them showed inhibition of PDE4 indicating the potential medicinal value of these novel polyazaheterocycles.