52196-76-6

Basic information

• Product Name: [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium
• CAS NO: 52196-76-6
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 207.2054
• Mol File: 52196-76-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium(52196-76-6)
• EPA Substance Registry System: [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium(52196-76-6)

Safety Data

• Hazardous Substances Data: 52196-76-6(Hazardous Substances Data)

Usage

Description

[2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium, with the molecular formula C10H12N2O5, is a diazeniumdiolate, a type of organic compound that contains a nitric oxide functional group. It serves as a crucial intermediate in the synthesis of nitric oxide-releasing drugs, which are being explored for their potential therapeutic applications in various medical conditions. [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium is characterized by the presence of a 3,4-dimethoxyphenyl group, which may contribute to its antioxidant and anti-inflammatory properties, although further research is necessary to comprehend its full biological impact.

Uses

Used in Pharmaceutical Industry:
[2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium is used as an intermediate in the synthesis of nitric oxide-releasing drugs for their potential therapeutic uses in various medical conditions. [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium's nitric oxide-releasing properties make it a promising candidate for the development of new medications.
Used in Antimicrobial Applications:
In the field of antimicrobial research, [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium is used as a potential agent due to its nitric oxide-releasing capabilities. Nitric oxide is known for its antimicrobial properties, making this compound a valuable asset in the development of new treatments against resistant infections.
Used in Cardiovascular Applications:
Within the cardiovascular industry, [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium is used as a potential vasodilator. Nitric oxide is a well-known vasodilator, and the compound's ability to release nitric oxide could lead to the development of new therapies for conditions such as hypertension and other cardiovascular diseases.
Used in Anti-inflammatory Applications:
In the area of anti-inflammatory research, [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium is used as a potential agent due to its suspected antioxidant and anti-inflammatory properties. The presence of the 3,4-dimethoxyphenyl group may enhance these effects, making it a valuable compound for the development of new treatments for inflammatory conditions.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of [2-(3,4-dimethoxyphenyl)-2-oxoethylidene]diazenium, it is used in the development of novel drug delivery systems. Various organic and metallic nanoparticles can be employed as carriers for this compound, aiming to improve its delivery and efficacy in targeted medical applications.

Upstream product

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 52751-63-0 1,3-di-(3,4-dimethoxyphenyl)-1,3-propanedione 
• 163428-90-8 2,2-dihydroxy-1-(3,4-dimethoxyphenyl)ethan-1-one 
• 93-07-2 Veratric acid 
• 186581-53-3 diazomethane 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 28891-68-1 1,2-Dibenzoyl-3-(3,4-dimethoxybenzoyl)-cyclopropan 
• 20931-30-0 2-(3,4-dimethoxy-phenyl)-3-hydroxy-5,7-dimethoxy-chromenylium; chloride 
• 7706-87-8 4-(3,4-dimethoxy-phenyl)-5H-furan-2-one 
• 37803-48-8 β-oxo-β-(3,4-dimethoxyphenyl)-ethanol 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 20601-92-7 2-(3,4-dimethoxyphenyl)-2-oxoethyl chloride 
• 23808-78-8 (4-chloro-phenyl)-[3-(4-chloro-phenyl)-4-(3,4-dimethoxy-phenyl)-3H-thiazol-2-ylidene]-amine 
• 23808-79-9 (4-bromo-phenyl)-[3-(4-bromo-phenyl)-4-(3,4-dimethoxy-phenyl)-3H-thiazol-2-ylidene]-amine 
• 39561-76-7 α-acetoxy-3,4-dimethoxyacetophenone 
• 6924-15-8 2-amino-1-(3,4-dimethoxy-phenyl)-ethanol 

Relevant articles and documents

Practical Application of the Aqueous 'Sulfonyl-Azide-Free' (SAFE) Diazo Transfer Protocol to Less α-C-H Acidic Ketones and Esters

The earlier described 'sulfonyl-Azide-free' ('SAFE') protocol for diazo transfer to CH-Acidic 1,3-dicarbonyl compounds (and their similarly activated congeners) has been extended to the less reactive monocarbonyl substrates, which previously required a se

One-pot synthesis of polyfunctional pyrazoles: An easy access to α-diazoketones from arylglyoxal monohydrates and tosylhydrazine

A new and efficient method for the generation of α-diazoketones has been developed from arylglyoxal monohydrates and tosylhydrazine at room temperature. 1,3-Dipolar cycloaddition reactions were used to constructing polyfunctional pyrazole derivatives by the reaction of generated α-diazoketones in situ with electron-deficient alkenes, quinones and coumarins in one pot. The one-dimensional molecular packing of 1H-benzo[f]indazole-4,9-dione derivatives along the c direction demonstrated a helical chain formation via N-H?O hydrogen-bonding.

Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

A series of CCK-B/gastrin receptor antagonists, 2,4-dioxo-1,5-benzodiazepine derivatives with a plane of symmetry, were designed, synthesized, and evaluated for antagonistic activity. Structure-activity relationship studies revealed that carbonylmethyl groups at both N-1 and N-5 positions and hydrophilic groups, such as the carboxyl group on the benzene ring attached to the ureido group at the C-3 position, brought about potent affinity and subtype selectivity for CCK-B/gastrin receptors. Several compounds showed excellent in vivo inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats.