52209-63-9

Basic information

• Product Name: N-methyl-N-(2-methylphenyl)carbamoyl chloride
• Synonyms: N-methyl-N-(2-methylphenyl)carbamoyl chloride
• CAS NO: 52209-63-9
• Molecular Weight: 183.637
• Mol File: 52209-63-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(2-methylphenyl)carbamoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(2-methylphenyl)carbamoyl chloride(52209-63-9)
• EPA Substance Registry System: N-methyl-N-(2-methylphenyl)carbamoyl chloride(52209-63-9)

Safety Data

• Hazardous Substances Data: 52209-63-9(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 611-21-2 N,2-dimethylaniline 
• 75-44-5 phosgene 

Downstream Products

• 1235712-66-9 3,4-dibutyl-1,8-dimethylquinolin-2(1H)-one 
• 120491-97-6 1,3-bis(2-methylphenyl)-1,3-dimethylurea 
• 22781-47-1 C₂₅H₃₄N₄O₄S 
• 1462366-86-4 (S)-2-{methyl[methyl(2-methylphenyl)carbamoyl]amino}-4-(methylsulfanyl)butanoic acid 
• 1462366-85-3 methyl (S)-2-{methyl[methyl(2-methylphenyl)carbamoyl]amino}-4-(methylsulfanyl)butanoate 
• 1462366-84-2 methyl (S)-2-{[methyl(2-methylphenyl)carbamoyl]amino}-4-(methylsulfanyl)butanoate 
• 1462366-70-6 (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylic acid 
• 1462366-69-3 benzyl (S)-1-(methyl(2-methylphenyl)carbamoyl)pyrrolidine-2-carboxylate 
• 42609-74-5 1-Methyl-3-(1-methyl-1-phenyl-ethyl)-1-o-tolyl-urea 
• 22781-45-9 4-[2-(3-Methyl-3-o-tolyl-ureido)-ethyl]-benzenesulfonamide 
• 859084-59-6 methyl-o-tolyl-carbamoyl azide 

Relevant articles and documents

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized, and their inhibitory activity was tested using lysates of HEK293 cells transiently expressing human ABHD6 (hABHD6). Among the compound series, 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate (JZP-430) potently and irreversibly inhibited hABHD6 (IC50 = 44 nM) and showed ～ 230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.

Iridium-catalyzed annulation of N -arylcarbamoyl chlorides with internal alkynes

An iridium complex successfully catalyzed the annulation of various N-arylcarbamoyl chlorides with internal alkynes to afford 2-quinolones in good to excellent yields. The present reaction is widely applicable to substrates with various functionalities. An amide-iridacycle complex was isolated, and it is likely that such an iridacycle species is a key intermediate in the catalytic reaction.