52215-41-5

Basic information

• Product Name: 3-Fluoro-5-methylaniline
• Synonyms: 3-FLUORO-5-METHYLANILINE;3-Amino-5-fluorotoluene;3-Fluoro-5-methylaniline98%;3-fluoro-5-aminotoluene;3-fluoro-5-MethylbenzenaMine;3-Amino-5-fluorotoluene, 5-Fluoro-m-toluidine;Benzenamine, 3-fluoro-5-methyl-
• CAS NO: 52215-41-5
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aniline
• Mol File: 52215-41-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 252.8°Cat760mmHg
• Flash Point: 106.7°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.226mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-methylaniline(52215-41-5)
• EPA Substance Registry System: 3-Fluoro-5-methylaniline(52215-41-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-27-36/37/39
• Hazardous Substances Data: 52215-41-5(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-methylaniline, also known as 3-fluoro-5-methylphenylamine, is a chemical compound with the molecular formula C7H8FN. It is a substituted aniline compound with a fluorine atom and a methyl group attached to the benzene ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of dyes, pigments, and other organic compounds. 3-Fluoro-5-methylaniline is a colorless to pale yellow liquid at room temperature and is considered to be harmful if swallowed, inhaled, or absorbed through the skin. It may cause irritation to the skin, eyes, and respiratory system, and proper safety precautions should be taken when handling this compound.

InChI:InChI=1/C7H8FN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3

Upstream product

• 202865-83-6 1-bromo-3-fluoro-5-methylbenzene 
• 618-61-1 3-methyl-5-nitro-aniline 
• 618-85-9 3,5-dinitrotoluene 
• 499-08-1 1-fluoro-3-methyl-5-nitrobenzene 

Downstream Products

• 93857-90-0 1-chloro-3-fluoro-5-methylbenzene 
• 1572509-84-2 3-(cyclopentylsulfamoyl)-N-(3-fluoro-5-methylphenyl)benzamide 
• 1214350-72-7 C₇H₆ClFO₂S 

Relevant articles and documents

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.