522644-14-0Relevant articles and documents
Synthesis of linear and cyclic hexapeptides with Nε-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl) -L-lysyl-β-alanyl as the repeating unit and properties of their iron(III) complexes
Katoh, Akira,Inoue, Yuichi,Nagashima, Hitoshi,Hikita, Yasushi,Ohkanda, Junko,Saito, Ryota
, p. 371 - 381 (2007/10/03)
Linear and cyclic hexapeptides including Nε(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl) -L-lysyl-β-alanyl as the repeating unit have been synthesized. These hexapeptides formed 1:1 iron(III) complexes; λmax 466 nm and ε 4700 for a linear hexapeptide (8), and λmax 458 nm and ε 4300 for a cyclic hexapeptide (9). The relative stability constants of 8- and 9-iron(III) complexes were estimated to be 26.1 and 28.0, respectively. A linear hexapeptide (8)-iron(III) complex predominantly existed in Δ-configuration. From kinetic data on iron(III) removal from human transferrin, a linear hexapeptides (8) was found to efficiently remove three times as much iron(III) from transferrin as desferrioxamine B, only a chemotherapeutic agent for the iron overload disease.