52279-18-2

Basic information

• Product Name: 5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat
• Synonyms: 5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat
• CAS NO: 52279-18-2
• Molecular Weight: 439.287
• Mol File: 52279-18-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat(52279-18-2)
• EPA Substance Registry System: 5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat(52279-18-2)

Safety Data

• Hazardous Substances Data: 52279-18-2(Hazardous Substances Data)

Upstream product

• 63927-23-1 5-bromo-8-nitroisoquinoline 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 104737-00-0 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline 
• 104737-02-2 5-Brom-2-methyl-8-nitro-1,2-dihydroisochinolin 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

Pyrrolo-isoquinoline compounds according to formula (I) wherein R3 is preferably a hydroxy radical and the southern ring is preferably a phenyl ring. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

190. Synthese einiger 8-substituierter 2-Methyl-1,2,3,4-tetrahydroisochinoline

A general route to 8-substituted tetrahydroisoquinolines is exemplified by preparetion of the 2-methyl-1,2,3,4-tetrahydroisoquinolin-8-ol (11), the -8-carbaldehyde oxime (12) and the -8-carbonitrile (13).It involves the conversion of isoquinoline (1) by partially modified Steps 1,2,3, and 5 (see the Scheme) into the 5-bromo-8-nitro derivative 5, reduction of the latter to the 8-amino derivative 8 and replacement of the NH2-group with an appropriate substituent by a Sandmeyer-like reaction.The selective reductions of the N-containing ring in 6 (Steps 5,6, and 8) and of the NO2-group in 5 (Steps 4 and 7) were also studied.