52286-74-5 Usage
Description
Ginsenoside Rg2, a protopanaxatriol, is a pharmacologically active natural compound found in ginseng and other plants of the genus Panax. It is a steroid glycoside derived from the triterpene squalene and is more abundant in certain Panax species, such as white and red P. ginseng. Ginsenoside Rg2 and its metabolites exhibit a range of in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-diabetic actions. Additionally, it offers protection against DNA damage and apoptosis induced by ultraviolet light. This ginsenoside is increased through the metabolism of other bioactive ginsenosides during the steaming or heating of plant materials, particularly in P. quinquefolium. Ginsenoside Rg2 exists as a white solid and is recognized as a bioactive metabolite of the ginsenoside component of Panax ginseng.
Uses
Used in Pharmaceutical Applications:
Ginsenoside Rg2 is used as an aldose reductase inhibitor, which may contribute to its anti-inflammatory and immunomodulatory activities. It is particularly beneficial in managing inflammation and modulating immune responses.
Used in Neuroprotection:
Ginsenoside Rg2 serves as a neuroprotective agent, safeguarding the nervous system from damage and promoting overall brain health.
Used in Anti-diabetic Applications:
As an anti-diabetic agent, Ginsenoside Rg2 helps in managing blood sugar levels and may contribute to the prevention or management of diabetes.
Used in Anti-inflammatory Applications:
Ginsenoside Rg2 is utilized for its anti-inflammatory properties, which can be beneficial in reducing inflammation and alleviating symptoms associated with various inflammatory conditions.
Used in Immunomodulatory Applications:
Ginsenoside Rg2 acts as an immunomodulatory agent, helping to regulate the immune system and support a balanced response to pathogens or foreign substances.
Used in DNA Protection:
Ginsenoside Rg2 is used to protect DNA from damage, particularly from the harmful effects of ultraviolet light, thus potentially reducing the risk of skin cancer and other related conditions.
Used in Cosmetics Industry:
Ginsenoside Rg2 can be used as an active ingredient in the cosmetics industry for its anti-aging, skin-soothing, and rejuvenating properties, contributing to healthier and more youthful-looking skin.
Used in Functional Foods and Supplements:
Ginsenoside Rg2 can be incorporated into functional foods and dietary supplements for its various health benefits, including enhanced immune function, improved cognitive function, and overall well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 52286-74-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,2,8 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52286-74:
(7*5)+(6*2)+(5*2)+(4*8)+(3*6)+(2*7)+(1*4)=125
125 % 10 = 5
So 52286-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C42H72O13/c1-20(2)11-10-14-42(9,51)22-12-16-40(7)28(22)23(44)17-26-39(6)15-13-27(45)38(4,5)35(39)24(18-41(26,40)8)53-37-34(32(49)30(47)25(19-43)54-37)55-36-33(50)31(48)29(46)21(3)52-36/h11,21-37,43-51H,10,12-19H2,1-9H3/t21-,22-,23+,24-,25+,26+,27-,28-,29-,30+,31+,32-,33+,34+,35-,36-,37+,39+,40+,41+,42-/m0/s1
52286-74-5Relevant articles and documents
Chemical transformation of ginsenoside Re by a heteropoly acid investigated using HPLC-MS: N/HRMS
Xiu, Yang,Zhao, Huanxi,Gao, Yue,Liu, Wenlong,Liu, Shuying
, p. 9073 - 9080 (2016)
The potential of heteropoly acid H3PW12O40 to catalyze the chemical transformation of ginsenoside Re into rare ginsenosides was explored. This homogeneous catalyst can be recycled by extraction with diethyl ether. Eight resulting products were separated and identified through a developed high-performance liquid chromatography coupled with multistage tandem mass spectrometry and high-resolution mass spectrometry (HPLC-MSn/HRMS) method. Multistage tandem mass spectrometry was employed to trace the source of fragments and determine fragmentation pathways. Also, high-resolution mass spectrometry was used for the accurate structural elucidation of fragments. Ginsenosides 25-OH-Rg6 and 25-OH-F4, consisting of the aglycone structures of 3β, 12β, 25-trihydroxy-dammar-20 (21/22)-ene , were obtained via chemical transformation for the first time. Chemical transformation pathways of ginsenoside Re were summarized, which involved deglycosylation, hydration, dehydration, and epimerization reactions. A carbenium ion mechanism was further employed to elucidate each transformation process, and the stability of carbenium ions was supposed to be responsible for the reaction pathways and selectivity.
Biotransformation of Ginsenosides Re and Rg1 into Rg2 and Rh1 by Thermostable β-Glucosidase from Thermotoga thermarum
Pei, Jianjun,Wu, Tao,Yao, Tao,Zhao, Linguo,Ding, Gang,Wang, Zhenzhong,Xiao, Wei
, p. 472 - 477 (2017)
The recombinant thermostable β-glucosidase from Thermotoga thermarum DSM 5069T exhibited high selectivity to catalyze the conversion of ginsenoside Re and Rg1 to the more pharmacologically active minor ginsenoside Rg2 and Rh1, respectively. At a concentration of 1.36 U/mL of the enzyme, a temperature of 85°C, and pH 5.5, 10 g/L ginsenoside Re was transformed into 8.02 g/L Rg2 within 60 min, and 2 g/L ginsenoside Rg1 was transformed into 1.56 g/L Rh1 within 60 min. This paper provides the first report on the production of ginsenoside Rg2 and Rh1 by a highly thermostable β-glucosidase.
