52287-52-2

Basic information

• Product Name: (E)-1,3-dichloro-2-(2-nitroethenyl)benzene
• Synonyms: (E)-1,3-dichloro-2-(2-nitroethenyl)benzene
• CAS NO: 52287-52-2
• Molecular Weight: 218.039
• Mol File: 52287-52-2.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (E)-1,3-dichloro-2-(2-nitroethenyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,3-dichloro-2-(2-nitroethenyl)benzene(52287-52-2)
• EPA Substance Registry System: (E)-1,3-dichloro-2-(2-nitroethenyl)benzene(52287-52-2)

Safety Data

• Hazardous Substances Data: 52287-52-2(Hazardous Substances Data)

Usage

Description

(E)-1,3-dichloro-2-(2-nitroethenyl)benzene, also known as 2,4-dichloro-2'-nitrostilbene, is a nitroalkene derivative of benzene with the molecular formula C8H5Cl2NO2. It is a yellow crystalline solid that is sparingly soluble in water but soluble in most organic solvents. This chemical compound is recognized for its role as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries.

Uses

Used in Pharmaceutical Industry:
(E)-1,3-dichloro-2-(2-nitroethenyl)benzene is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, (E)-1,3-dichloro-2-(2-nitroethenyl)benzene serves as a precursor in the production of certain agrochemicals. Its application in this industry aids in the development of products that can enhance crop protection and contribute to increased agricultural productivity.
Used in Research and Development:
(E)-1,3-dichloro-2-(2-nitroethenyl)benzene is also utilized in research and development settings. Its properties make it a valuable compound for exploring new reactions and syntheses, potentially leading to the discovery of novel organic compounds with various applications.
Caution:
It is crucial to handle (E)-1,3-dichloro-2-(2-nitroethenyl)benzene with care, as it is known to be toxic and can pose risks to human health and the environment. Proper safety measures and protocols should be followed to minimize potential hazards during its use and disposal.

Upstream product

• 1029580-46-8 1-(2,6-dichlorophenyl)-2-nitroethan-1-ol 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 28469-92-3 2,6-dichlorostyrene 
• 75-52-5 nitromethane 

Downstream Products

• 53960-48-8 β-(2,6-dichlorophenyl)-β-(pyrazolyl-1)-nitroethane 
• 120355-51-3 2-(2,6-Dichloro-phenyl)-2-phenyl-ethylamine 
• 163129-82-6 (2,6-dichlorophenethyl)(4-pyridin-yl-methylene)amine 

Relevant articles and documents

Skeletally Tunable Seven-Membered-Ring Fused Pyrroles

We describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.

Compound containing FXR agonist, and preparation method and application thereof

The invention belongs to the technical field of medicines, and concretely relates to a compound containing an FXR agonist, represented by general formula (I), or a pharmaceutically acceptable salt thereof, a preparation method of the compounds, a pharmaceutical composition and a pharmaceutical preparation containing the compounds, and an application of the compounds in the preparation of drugs used for treating and/or preventing FXR mediated diseases. R, R, R, R, m, n, p, q, T, L1-L2 and A ring or B ring in the formula (I) are defined in the description.

NHC-Catalyzed Dual Stetter Reaction: A Mild Cascade Annulation for the Syntheses of Naphthoquinones, Isoflavanones, and Sugar-Based Chiral Analogues

The N-heterocycle carbene (NHC)-catalyzed dual Stetter cascade reaction is discovered through coupling of β-nitrostyrene with phthalaldehyde under mild conditions to furnish valuable aryl-naphthoquinones. The generality of the new reaction is validated through the development of a C-C and O-C bond forming Stetter cascade reaction using salicylaldehydes to obtain functionalized dihydroisoflavanones. The mild NHC organocatalysis is successfully employed for the construction of optically pure sugar-based naphthoquinones and dihydroisoflavanones. Herein, NHC is found as a unique and powerful organocatalyst to construct homoatomic C-C cross-coupling, heteroatomic O-C bond formation, and cascade cyclization utilizing NO2 as a leaving group at ambient temperature. A mechanistic pathway of the new metal-free catalysis is predicted on the basis of our ESI-MS study of the ongoing reaction and literature.