52372-97-1Relevant articles and documents
ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT
-
Paragraph 0261; 0262; 0263; 0264; 0265, (2021/01/25)
The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group, R1 particularly being H or (C1-C6)alkyl group;A1 being an —NH— radical or —NH—CH2— radical;Cy1 particularly being a phenyl group,A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.
Preparation of optical homochiral amine
-
Paragraph 0006, (2017/03/08)
The invention discloses a preparation method of an optical homochiral amine R-5-methoxy-1-naphthalenamine. The method concretely comprises the following steps: carrying out reducing ammonification on a raw material 5-methoxy-1-tetralone to obtain rac-5-methoxy-1-tetralone, and carrying out enzyme-catalyzed dynamic kinetic resolution on the above racemic amine to obtain R-5-methoxy-1-naphthalenamine. The method has the characteristics of simplicity in operation, easily available raw materials, and realization of good yield and high optical purity of the above product.
PYRIMIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE
-
Paragraph 00206, (2013/10/22)
The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.