52373-02-1

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE
• Synonyms: 1-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6-METHOXY-;1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE;CHEMBRDG-BB 4102674;(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amine(SALTDATA: HCl);(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amine 1HCl;(+/-)-6-Methoxy-1,2,3,4-tetrahydro-1-naphthalenylamine;6-Methoxy-1-aminotetralin;(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)azanium chloride
• CAS NO: 52373-02-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 52373-02-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 300.9 °C at 760 mmHg
• Flash Point: 140.8 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE(52373-02-1)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE(52373-02-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 52373-02-1(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-6-methoxy-1-naphthalenamine, also known as 6-Methoxy-1,2,3,4-tetrahydro-1-naphthylamine, is a chemical compound with the molecular formula C12H15NO. It falls under the category of organic compounds known as methoxyphenols, characterized by a methoxy group attached to the benzene ring of a phenol moiety. 1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE has not been fully explored, hence its physical and chemical properties, toxicity, and applications are not comprehensively documented. As with all chemicals, it should be handled under proper safety precautions and guidance. Please refer to Material Safety Data Sheet (MSDS) for any additional information on handling and potential hazards.

InChI:InChI=1/C11H15NO/c1-13-9-5-6-10-8(7-9)3-2-4-11(10)12/h5-7,11H,2-4,12H2,1H3

Upstream product

• 120342-64-5 1-azido-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 536717-83-6 O-tert-butyldimethylsilyl-6-methoxy-1-tetralone oxime 
• 1730-48-9 6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 16821-32-2 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 

Downstream Products

• 314019-11-9 (S)-6-methoxy-1,2,3,4-tetrahydro-1-naphthylamine 
• 39226-88-5 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-ylamine hydrochloride 

Relevant articles and documents

PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX) / histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Facile rearrangement of O-silylated oximes on reduction with boron trifluoride/borane

Aromatic O-triisopropylsilyl ketoximes were efficiently rearranged to cyclic and acyclic aniline derivatives on reduction with BF3- ethearate /borane. The bulk of the substituents on the silicon atom, the size of the aliphatic ring, and the presence of alkoxy substituents on the aryl group all play an important role in the aniline.

Selective Conversion of Benzylic C-H Bonds to an Amine Function by Oxidative Nucleophilic Substitution

The benzylic proton of alkylarenes 1 was replaced by an azido group in one step by reaction with trimethylsilyl azide or hydrazoic acid in chloroform in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).The 1-arylalkyl azides 2 were reduced to amines 3, which were characterized as their hydrochlorides 4.