52378-43-5

Basic information

• Product Name: N-desmethylcimetidine
• Synonyms: N-desmethylcimetidine;N-CYANO-N''-[2-[[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO]ETHYL]GUANIDINECIMETIDINE
• CAS NO: 52378-43-5
• Molecular Formula: C9H14N6S
• Molecular Weight: 238.318
• Mol File: 52378-43-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 506.3°C at 760 mmHg
• Flash Point: 260°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 2.26E-10mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: N-desmethylcimetidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-desmethylcimetidine(52378-43-5)
• EPA Substance Registry System: N-desmethylcimetidine(52378-43-5)

Safety Data

• Hazardous Substances Data: 52378-43-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H14N6S/c1-7-8(15-6-14-7)4-16-3-2-12-9(11)13-5-10/h6H,2-4H2,1H3,(H,14,15)(H3,11,12,13)

Upstream product

• 38585-67-0 4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole 
• 52378-40-2 N-Cyano-N'-<2-<(5(4)-methyl-4(5)-imidazolyl)-methylthio>-ethyl>-S-methyl-isothioharnstoff 
• 38585-67-0 4-methyl-5-<(2-aminoethyl)-thiomethyl>-imidazole 
• 112528-12-8 N-cyano-N'-{2-[(4-methyl-5-imidazolyl)methylthio]ethyl}-S-methyl isothiourea 

Relevant articles and documents

H2-antihistaminics, VII: Synthesis and H2-antihistaminic activity of N,N'-substituted thioureas, cyanoguanidines and dithiooxamides

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PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.

PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. "