52427-01-7

Basic information

• Product Name: 2-(BROMOMETHYL)-1-CHLORO-4-NITROBENZENE
• Synonyms: 2-(BROMOMETHYL)-1-CHLORO-4-NITROBENZENE;2-Chloro-5-nitrobenzylbromide;Benzene, 2-(broMoMethyl)-1-chloro-4-nitro-
• CAS NO: 52427-01-7
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.48
• Mol File: 52427-01-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 85-87°C
• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 152.8 °C
• Appearance: /
• Density: 1.755 g/cm³
• Vapor Pressure: 0.000349mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(BROMOMETHYL)-1-CHLORO-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-1-CHLORO-4-NITROBENZENE(52427-01-7)
• EPA Substance Registry System: 2-(BROMOMETHYL)-1-CHLORO-4-NITROBENZENE(52427-01-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 52427-01-7(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-1-chloro-4-nitrobenzene is a chemical compound with the molecular formula C7H5BrClNO2. It is a yellow solid at room temperature and is commonly used in organic synthesis as an intermediate for the production of pharmaceuticals, agrochemicals, and dyes. 2-(Bromomethyl)-1-chloro-4-nitrobenzene is a derivative of benzene, with a bromomethyl group, a chlorine atom, and a nitro group attached to the benzene ring. It is important to handle this chemical with care as it is toxic and may cause irritation to the skin, eyes, and respiratory system. Additionally, it is important to be aware of the potential environmental impact and disposal regulations associated with this chemical.

InChI:InChI=1/C7H5BrClNO2/c8-4-5-3-6(10(11)12)1-2-7(5)9/h1-3H,4H2

Upstream product

• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 

Downstream Products

• 52427-02-8 2-chloro-5-nitro-benzeneacetonitrile 
• 642084-74-0 3-[(2-chloro-5-nitrophenyl)methoxy]pyridine 
• 52427-07-3 (2-morpholin-4-yl-5-nitro-phenyl)-acetic acid 
• 37777-70-1 2-(2-chloro-5-nitrophenyl)acetic acid 
• 622861-50-1 2-[(E)-2-(2-chloro-5-nitrophenyl)ethenyl]-5-methoxy-1H-indole 
• 622861-52-3 4-(2-chloro-5-nitrophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione 
• 622861-51-2 4-(2-chloro-5-nitrophenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione 
• 642084-31-9 4-chloro-3-[(pyridin-3-yloxy)methyl]aniline 
• 1097810-28-0 1-(2-chloro-5-nitro-benzyl)-pyrrolidine 
• 1138471-32-5 1-(2-chloro-5-nitro-benzyl)-4-isopropyl piperazine 
• 1097788-41-4 1-(2-chloro-5-nitro-benzyl)-1H-imidazole 
• 1138471-36-9 tert-butyl-(2-chloro-5 nitro-benzyl)-amine 
• 1097798-35-0 2-{[(2-chloro-5-nitrophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol 

Relevant articles and documents

CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

SUBSTITUTED PYRROLO[1,2-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted pyrrolo[l,2-a]pyrimi dines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[l,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.