52449-77-1

Basic information

• Product Name: 2-Cyano-3-hydroxynaphthalene
• Synonyms: 2-Cyano-3-hydroxynaphthalene;3-Hydroxy-2-naphthonitrile
• CAS NO: 52449-77-1
• Molecular Formula: C₁₁H₇NO
• Molecular Weight: 169.17938
• Mol File: 52449-77-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Cyano-3-hydroxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3-hydroxynaphthalene(52449-77-1)
• EPA Substance Registry System: 2-Cyano-3-hydroxynaphthalene(52449-77-1)

Safety Data

• Hazardous Substances Data: 52449-77-1(Hazardous Substances Data)

Usage

Description

2-Cyano-3-hydroxynaphthalene is a chemical compound with the molecular formula C12H7NO. It is a naphthalene derivative that contains a cyano group and a hydroxyl group on the aromatic ring.

Uses

Used in Organic Synthesis:
2-Cyano-3-hydroxynaphthalene is used as a precursor for the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
2-Cyano-3-hydroxynaphthalene is used as a building block for the development of pharmaceuticals.
Used in Dye Industry:
2-Cyano-3-hydroxynaphthalene is used as a precursor for the production of dyes.
Used in Research:
2-Cyano-3-hydroxynaphthalene is used as a fluorescent probe in research due to its ability to emit light in the visible spectrum when exposed to ultraviolet or blue light.
Safety Precautions:
2-Cyano-3-hydroxynaphthalene is considered to be a potentially hazardous chemical and should be handled with caution due to its potential health and environmental risks.

Upstream product

• 3665-51-8 3-hydroxy-2-naphthalenecarboxamide 
• 53855-64-4 3-acetoxy-2-naphthoyl chloride 
• 7163-25-9 ethyl 3-hydroxy-2-naphthanoate 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 5464-07-3 3-acetoxy-2-naphthoic acid 
• 175293-41-1 3-carbamoylnaphthalen-2-yl acetate 
• 92616-44-9 3-methoxy-2-naphthonitrile 
• 628-13-7 pyridine hydrochloride 

Downstream Products

• 3665-51-8 3-hydroxy-2-naphthalenecarboxamide 

Relevant articles and documents

Bi-aryl analogues of salicylic acids: Design, synthesis and sar study to ameliorate endoplasmic reticulum stress

Introduction: Endoplasmic reticulum (ER) stress condition is characterized as the accu-mulation of misfolded or unfolded proteins in lumen of ER. This condition has been implicated in various diseases and pathologies including β-cell apoptosis, Alzheimer’s disease and atherosclerosis. We have reported that hydroxynaphthoic acids (HNA), naphtha-lene analogues of salicylic acid (SA), reduced ER stress. In this study, we explored structural modification to bi-aryl analogues of SA. Methods: Palladium-catalyzed cross-coupling was applied to synthesize bi-aryl analogues of SA. Anti-ER stress activity was monitored by using our cell-based assay system where ER stress is induced by tunicamycin. To monitor ER stress markers, ER stress was induced physiologically relevant palmitate system. Results: Many analogues decreased ER stress signal induced by tunicamycin. Compounds creating dihedral angle between Ar group and SA moiety generally increased the activity but gave some cytotoxicity to indicate the crucial role of flat conformation of aromatic region. The best compound (16e) showed up to almost 6-fold and 90-fold better activity than 3-HNA and tauro-ursodeoxycholic acid, positive controls, respectively. ER stress markers such as p-PERK and p-JNK were accordingly decreased in Western blotting upon treatment of 16e under palmitate-induced condition. Conclusion: Anti-ER stress activity and toxicity profile of bi-aryl analogues of SA could provide a novel platform for potential therapy for protein misfolding diseases.

Thiazoline acid derivatives

Thiazoline acids and derivatives useful as chelators of trivalent metals in therapeutic applications have been prepared.