524685-48-1

Basic information

• Product Name: N-(3-ethynylphenyl)-2,2-dichloroacetamide
• Synonyms: N-(3-ethynylphenyl)-2,2-dichloroacetamide
• CAS NO: 524685-48-1
• Molecular Weight: 228.078
• Mol File: 524685-48-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(3-ethynylphenyl)-2,2-dichloroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-ethynylphenyl)-2,2-dichloroacetamide(524685-48-1)
• EPA Substance Registry System: N-(3-ethynylphenyl)-2,2-dichloroacetamide(524685-48-1)

Safety Data

• Hazardous Substances Data: 524685-48-1(Hazardous Substances Data)

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 54060-30-9 3-acetylenephenylamine 

Downstream Products

• 1374114-57-4 4-[3-(2,2-dichloroacetamido)phenyl]-1H-1,2,3-triazol-1-yl-2-(difluoromethyl)phenyl 5-acetoamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid 
• 793708-40-4 C₂₉H₂₆Cl₃N₃O₂ 
• 793708-88-0 2,2-dichloro-N-[2-[3-(2-chloro-6-(4-pyridyl)phenyl)-5-isoxazolyl]phenyl]acetamide 
• 1394382-37-6 (+/-)-2,2-dichloro-N-benzyl-N-[3-[3-(2,6-dichlorophenyl)-5-(4-isoxazolinyl)]phenyl]acetamide 

Relevant articles and documents

Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation

A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC50 > 1000 μM for A549). In this paper, a variety of DCA derivatives were synthesized, and their cytotoxic activities were evaluated. The result showed that the N-phenyl-2,2-dichloroacetamide analogues had satisfactory potencies. Among them, N-(3-iodophenyl)-2,2-dichloroacetamide (3e), an optimized lead compound, has an IC50 against A549 as low as 4.76 μM. Furthermore, it can induce cancer cell apoptosis and has a low toxicity in mice (LD50 = 1117 mg/kg). N-phenyl-2,2-dichloroacetamide analogues has higher cytotoxic activity and N-(3-iodophenyl)-2,2-dichloroacetamide (3e) is an optimized lead compound.

HETEROCYCLIC COMPOUNDS AND HYDRO ISOMERS THEREOF

The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.