524774-14-9

Basic information

• Product Name: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-pyridin-4-yl-propionic acid ethyl ester
• CAS NO: 524774-14-9
• Molecular Weight: 773.74
• Mol File: 524774-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-pyridin-4-yl-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-pyridin-4-yl-propionic acid ethyl ester(524774-14-9)
• EPA Substance Registry System: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-pyridin-4-yl-propionic acid ethyl ester(524774-14-9)

Safety Data

• Hazardous Substances Data: 524774-14-9(Hazardous Substances Data)

Upstream product

• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 524774-00-3 [2-(1-{4-[(3,4-bis-difluoromethoxy-phenyl)-chloro-methyl]-2-methyl-phenyl}-2,2,2-trifluoro-1-trifluoromethyl-ethoxymethoxy)-ethyl]-trimethyl-silane 
• 524773-85-1 (3,4-bis-difluoromethoxy-phenyl)-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-methanol 
• 524773-72-6 {2-[1-(4-bromo-2-methyl-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethoxymethoxy]-ethyl}-trimethyl-silane 
• 604799-58-8 2-(4-bromo-2-methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 615-59-8 1,4-dibromo-2-methylbenzene 
• 127842-54-0 3,4-bis-(difluoromethoxy)-benzaldehyde 

Downstream Products

• 524774-28-5 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{3-methyl-4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridine 

Relevant articles and documents

Substituted 4-(2,2-Diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models.