524940-50-9

Basic information

• Product Name: 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester
• Synonyms: 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester
• CAS NO: 524940-50-9
• Molecular Weight: 463.467
• Mol File: 524940-50-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester(524940-50-9)
• EPA Substance Registry System: 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester(524940-50-9)

Safety Data

• Hazardous Substances Data: 524940-50-9(Hazardous Substances Data)

Upstream product

• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 538-60-3 dibenzyl hydrogen phosphite 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 3850-40-6 N-Boc-DL-serine 

Downstream Products

• 596807-19-1 3-(bis-benzyloxy-phosphoryl)-2-({2-[(6-{2-(bis-benzyloxy-phosphoryl)-1-[2-(bis-benzyloxy-phosphoryl)-1-carboxy-ethylcarbamoyl]-ethylcarbamoyl}-1-methyl-1H-benzoimidazol-2-yl)-difluoro-methyl]-3H-benzoimidazole-5-carbonyl}-amino)-propionic acid 
• 524940-49-6 C₇₁H₇₀F₂N₇O₁₆P₃ 
• 524940-48-5 2-({6-[2-(bis-benzyloxy-phosphoryl)-1-methoxycarbonyl-ethylcarbamoyl]-1H-benzoimidazol-2-yl}-difluoro-methyl)-3-methyl-3H-benzoimidazole-5-carboxylic acid tert-butyl ester 
• 596803-03-1 2-({6-[2-(bis-benzyloxy-phosphoryl)-1-methoxycarbonyl-ethylcarbamoyl]-1H-benzoimidazol-2-yl}-difluoro-methyl)-3-methyl-3H-benzoimidazole-5-carboxylic acid 
• 524940-52-1 3-(bis-benzyloxy-phosphoryl)-2-[3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionylamino]-propionic acid methyl ester 
• 524940-46-3 2-[2-amino-3-(bis-benzyloxy-phosphoryl)-propionylamino]-3-(bis-benzyloxy-phosphoryl)-propionic acid methyl ester 
• 524940-51-0 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid 
• 160515-05-9 2-amino-3-(bis-benzyloxy-phosphoryl)-propionic acid methyl ester 

Relevant articles and documents

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease

Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn2+-dependent inhibitor (1). Optimization of this screening hit afforded a 10-fold more potent inhibitor (46) under Zn2+ conditions (Ki=27 nM). This compound (46) binds also to NS3/NS4A in a Zn2+ independent fashion (Ki=1 μM). The SAR of this class of compounds under Zn2+ conditions is highly divergent compared to the SAR in the absence of Zn2+, suggesting two distinct binding modes.