5251-81-0

Basic information

• Product Name: 4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride
• Synonyms: MAUKRAODYPUHJG-UHFFFAOYSA-N
• CAS NO: 5251-81-0
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 297.8467
• Mol File: 5251-81-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 418.3°C at 760 mmHg
• Flash Point: 206.8°C
• Vapor Pressure: 3.33E-07mmHg at 25°C
• CAS DataBase Reference: 4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride(5251-81-0)
• EPA Substance Registry System: 4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride(5251-81-0)

Safety Data

• Hazardous Substances Data: 5251-81-0(Hazardous Substances Data)

Usage

Description

4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride is a chemical compound with a complex molecular structure, characterized by its unique arrangement of atoms and functional groups. It belongs to the class of thienopyrimidine derivatives, which are known for their diverse biological activities and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Research and Development:
In the field of research and development, 4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride serves as a valuable compound for studying the structure-activity relationships of thienopyrimidine derivatives. This knowledge can be applied to design and develop novel drugs with improved pharmacological properties.
Used in Synthesis of Cefixime Ethyl Ester Sodium Salt:
4-azepan-1-yl-6-ethylthieno[2,3-d]pyrimidine hydrochloride is used as an intermediate in the synthesis of Ethyl 2-((1,3-Dioxoisoindolin-2-yl)oxy)acetate, which is an ester impurity of the third-generation cephalosporin antibiotic, Cefixime (C242800). This application highlights its importance in the development of antibiotics and their derivatives.

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 623-50-7 ethyl 2-hydroxyacetate 
• 105-36-2 ethyl bromoacetate 
• 70206-52-9 sodium salt of 2-hydroxy-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 5740-47-6 ethyl 2-(aminooxy)-acetate 
• 645-88-5 aminooxyacetic acid 
• 136918-14-4 phthalimide 
• 924-44-7 glyoxylic acid ethyl ester 
• 3919-73-1 O-Ethoxycarbonylmethylhydroxylamine hydrochloride 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 

Relevant articles and documents

Design of a "new motif" with β-amino acids and α-aminoxy acids: Synthesis of hybrid peptides with 12/10-helix

(Figure Presented) Hybrid peptides are prepared from a C-linked carbo-β-amino acid ester (R-β-Caa) and an α-aminoxy acid (R-Ama) derived from S-lactic acid. Extensive NMR (in CDCl3 solution), CD, and MD studies on the tetra- and hexapeptides led to identification of robust 12/10-mixed helices. The dipeptide repeat having an R-β-Caa and an R-Ama thus provides a "new motif" to realize a 12/10-mixed helix, for the first time, in oligomers containing R-Ama. To understand the impact of side chains in the mixed helix formation, R-β-Caa/Ama (with no substitution in Ama) and S-β-hAla/R-Ama oligomers were investigated. NMR studies revealed the existence of 12/10-helices in these hybrid peptides, and the side chains of monomers were found to have a profound influence on their stabilities. These observations imply that the propensity of β-amino acid to prefer a mixed 12/10-helix governs the structural behavior in these peptides. The structural consequences of the lone-pair repulsion between nitrogen and oxygen atoms result in a new and interesting structural motif which behaves like "pseudo" β3,β2-peptides in generating 12/10-mixed helices.

Substituted benzimidazole compound and composition with compound

The invention provides a substituted benzimidazole compound and a composition with the compound. The substituted benzimidazole compound is a compound of formula (I) as shown in the specification, or apharmaceutically acceptable salt, prodrug, aquo-complex or solvent compound, polycrystalline type compound, stereisomer or isotope variant of the compound. The compound provided by the invention canbe adopted to treat and/or prevent related diseases caused by MEK (Methyl Ethyl Ketone), such as excessive proliferative diseases, pancreatitis, kidney illness, blastocyte cell transplantation and angiogenesis or angiopoiesis related diseases.

NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR

-