5254-86-4Relevant articles and documents
Method for preparing sulfhydryl compounds by hydroxyl substitution and sulfhydryl compounds
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Paragraph 0073; 0074; 0075, (2017/06/02)
The invention provides a method for preparing sulfhydryl compounds by hydroxyl substitution and the sulfhydryl compounds. According to the method, low-cost and easily-obtained benzene or fused ring compounds with phenolic hydroxyl groups or benzyl hydroxyl substituents serving as raw materials to react with the raw materials such as inorganic sulfide under the catalysis conditions to prepare the corresponding sulfhydryl compounds. The method has the advantages that the preparation method is simple, convenient and rapid, low in cost, mild in reaction condition, high in reaction site selectivity and high in yield, a post-processing process is simple, and no pollution is caused.
Allylic protection of thiols and cysteine: II: The N-[2,3,5,6- tetrafluoro-4-(N'-piperidino)-phenyl], N-allyloxycarbonylaminomethyl (Fnam) group
Gomez-Martinez, Paloma,Kimbonguila, Andre Malanda,Guibe, Francois
, p. 6945 - 6960 (2007/10/03)
S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)-phenyl], N- allyloxycarbonyl]-aminomethyl (Fnam) derivatives of thiols in general and cysteine in particular are readily deprotected by palladium catalysed allylic cleavage in the presence of various nucleophilic species. They are perfectly stable in both the basic conditions (piperidine/DMF) of Fmoc group removal and the acidic conditions (TFA/CH2Cl2) of t-Bu and Boc group removal.
Photoextrusion of SO2 from Arylmethyl Sulfones: Exploration of the Mechanism by Chemical Trapping, Chiral, and CIDNP Probes
Givens, Richard S.,Hrinczenko, Borys,Liu, Jerry H.-S.,Matuszewski, Bogdan,Tholen-Collison, Joan
, p. 1779 - 1789 (2007/10/02)
The photochemistry of eight benzylic sulfones, all of which efficiently extrude sulfur dioxide, was studied by a variety of methods.Optically active sulfones (S)-(-)-8, (S)-(-)-11, (S)-(-)-12, (S)-(+)-13, and (R)-(+)-14 were employed to measure the extent of the "hidden" return of the initial photogenerated intermediates by the stereoequilibration of the chiral center.By comparison of the regioisomeric methyl sulfones 11 vs. 13 and 12 vs. 14, preferential C-S bond fragmentation on the naphthyl side was established for the singlet excited sulfones.Added nucleophilic and proton trapping agents had no effect on the course of the reaction, ruling out ionic intermediates.The three hydrocarbon products of photodesulfonation from the unsymmetrical sulfones 8-14 provided a measure of the cage effects, which were highly structure and multiplicity dependent.Rate constants for reaction, and fluorescence, as well as the energy transfer rates from benzophenone were determined.The reaction rate constant for singlet reactivity from the 1-naphthyl sulfones was about three times greater than that for the 2-naphthyl derivatives.CIDNP studies showed a strong product signal for the 1-naphthyl sulfones from desulfonation of a triplet caged radical pair.Naphthaldehyde formation, a very minor, triplet process, was also detected by the CIDNP study of sulfones 9-12.