52558-70-0

Basic information

• Product Name: N-dodecanoyl-4-aminobutyric acid
• Synonyms: N-dodecanoyl-4-aminobutyric acid
• CAS NO: 52558-70-0
• Molecular Formula: C16H31 N O3
• Molecular Weight: 285.42
• Mol File: 52558-70-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 76-78 °C
• Boiling Point: 481.3°Cat760mmHg
• Flash Point: 244.9°C
• Appearance: /
• Density: 0.973g/cm³
• Vapor Pressure: 1.38E-10mmHg at 25°C
• Refractive Index: 1.467
• PKA: 4.66±0.10(Predicted)
• CAS DataBase Reference: N-dodecanoyl-4-aminobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-dodecanoyl-4-aminobutyric acid(52558-70-0)
• EPA Substance Registry System: N-dodecanoyl-4-aminobutyric acid(52558-70-0)

Safety Data

• Hazardous Substances Data: 52558-70-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H31NO3/c1-2-3-4-5-6-7-8-9-10-12-15(18)17-14-11-13-16(19)20/h2-14H2,1H3,(H,17,18)(H,19,20)

Upstream product

• 143-07-7 lauric acid 
• 56-12-2 4-amino-n-butyric acid 
• 112-16-3 n-dodecanoyl chloride 

Relevant articles and documents

SYNTHESIS AND PHARMACOLOGICAL STUDY OF &γ-CARBOXYPROPYLAMIDES OF HIGHER FATTY ACIDS

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Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives

Several 1-acyl-2-pyrrolidinone derivatives were synthesized as derivatives of γ-aminobutyric acid (GABA), and their pharmacological activities and stabilities were investigated. The derivatives showed anticonvulsant effect on picrotoxin-induced seizure at a dose of 200 mg/kg. In particular, 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) had a high activity. The anticonvulsant activity showed a dose dependency. Some of 1-acyl-2-pyrrolidinone derivatives prolonged sleeping time which was induced by sodium pentobarbital and showed a recovery from disruption of the memory of passive avoidance response, which was induced by an electroconvulsive shock. As shown by the results of the stability study of 1-acetyl-2-pyrrolidinone (1), it was degraded in an acidic buffer and an alkaline buffer although 2-pyrrolidinone was stable. 1-Acyl-2-pyrrolidinone derivatives were degraded in liver and brain homogenates of mouse and rat. They showed a degradation rate in rat plasma. Conversion of 8 to GABA in mouse liver homogenate was demonstrated. These results suggested that the pharmacological activity of 1-acyl-2-pyrrolidinone is probably due to the release of GABA by hydrolysis of derivatives although further work is necessary.