52596-95-9

Basic information

• Product Name: 1,3,4-Oxadiazole, 2-(4-chlorophenyl)-5-(4-methylphenyl)-
• CAS NO: 52596-95-9
• Molecular Formula: C15H11ClN2O
• Molecular Weight: 270.718
• Mol File: 52596-95-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazole, 2-(4-chlorophenyl)-5-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazole, 2-(4-chlorophenyl)-5-(4-methylphenyl)-(52596-95-9)
• EPA Substance Registry System: 1,3,4-Oxadiazole, 2-(4-chlorophenyl)-5-(4-methylphenyl)-(52596-95-9)

Safety Data

• Hazardous Substances Data: 52596-95-9(Hazardous Substances Data)

Usage

Chemical structure

A heterocyclic organic compound with a five-membered ring containing oxygen, nitrogen, and two carbon atoms.

Molecular weight

269.7 g/mol

Functional groups

1,3,4-Oxadiazole, 4-chlorophenyl, and 4-methylphenyl groups

Application

Used in the pharmaceutical industry as a building block for the synthesis of various bioactive molecules, such as pharmaceuticals and agrochemicals.

Versatility

Its structure and properties make it a versatile intermediate for the development of new drugs and agrochemicals with potential therapeutic and agricultural applications.

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 3619-22-5 p-toluic hydrazide 
• 51771-25-6 4-Methyl-benzoic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 74-11-3 para-chlorobenzoic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 23289-10-3 2-(4-chlorophenyl)-1,3,4-oxadiazole 
• 25563-06-8 N-methoxy-4-methylbenzamide 
• 77420-62-3 N'-(4-methylbenzylidene)-4-chlorobenzohydrazide 
• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 624-31-7 4-tolyl iodide 
• 14062-78-3 N,N-dimethyl-4-toluamide 
• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 

Downstream Products

• 59098-62-3 2-(4-chloro-phenyl)-5-{4-[2-(5-methyl-2-phenyl-2H-[1,2,3]triazol-4-yl)-vinyl]-phenyl}-[1,3,4]oxadiazole 
• 65205-01-8 2-(4-chloro-phenyl)-5-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 65205-05-2 2-(4-chloro-phenyl)-5-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 65205-18-7 2-(4-chloro-phenyl)-5-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 65205-22-3 2-(4-chloro-phenyl)-5-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 59098-56-5 2-(4-chloro-phenyl)-5-{4-[2-(2-phenyl-2H-[1,2,3]triazol-4-yl)-vinyl]-phenyl}-[1,3,4]oxadiazole 
• 59151-80-3 2-(4-chloro-phenyl)-5-{4-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 59151-72-3 2-(4-chloro-phenyl)-5-{4-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,3,4]oxadiazole 
• 37430-95-8 2-(4-{4-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-2H-naphtho[1,2-d][1,2,3]triazole 

Relevant articles and documents

Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes

A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.

Ligand-free Cu(ii)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N′-diacylhydrazines and 1,3,4-oxadiazoles

A Cu(ii)-mediated synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles from aldehyde hydrazones has been developed. This is the first time that the synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles using N,N-dimethylamides as the acylation reagent and O2 in air as the oxidation reagent is reported. These reactions offered several advantages including simple workups, ligand-free inexpensive metal salts as mediators, high yields, and wide scope of substrates.

Ligand-free copper(0) catalyzed direct C-H arylation of 1,2,4-triazoles and 1,3,4-oxadiazoles with aryl iodides in PEG-400

A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction medium. The procedure is experimentally simple and free from addition of external chelating ligands or co-catalysts.