526224-44-2Relevant articles and documents
A mild and practical method for the regioselective synthesis of N-acylated 3,4-dihydropyrimidin-2-ones. New acyl transfer reagents
Singh, Kamaljit,Singh, Sukhdeep
, p. 8143 - 8146 (2006)
The treatment of 3,4-dihydropyrimidin-2-ones with n-BuLi at -78 °C, followed by quenching with various electrophiles furnished N3-substituted derivatives, regioselectively. Further, N1,N3-diacyl derivatives were found to transfer N1-acyl groups to nucleop
Efficient and convenient synthesis of N3-(acyloxymethyl) dihydropyrimidinones by a one-pot two-step method
Quan, Zheng-Jun,Ren, Rong-Guo,Da, Yu-Xia,Zhang, Zhang,Wang, Xi-Cun
, p. 188 - 192 (2012/04/04)
3,4-Dihydropyrimidinones modified with N3-(acetoxymethyl) and (aroyloxymethyl) groups can be regioselectively obtained in good yields by reactions of 3,4-dihydropyrimidinones with paraformaldehyde and substituted benzoic acids/acetic acid, by a one-pot two-step strategy in the presence of chlorotrimethylsilane. The advantages of this method are the simple procedure, the high regioselectivity of the products, shorter reaction time and the mild reaction conditions. Additionally, this method directly uses acid as acylation reagents and needs not acid anhydride or acyl chloride.
QSAR analysis of 2-oxo-1,2,3,4-tetrahydropyrimidine analogues of antibacterials
Sawant, Ramesh L.,Bhatia, Manish S.
experimental part, p. 1361 - 1373 (2010/04/28)
QSAR analysis of two sets of analogues of 2-oxo-1,2,3,4- tetrahydropyrimidine was performed to investigate the relationship between their physicochemical parameters and antibacterial activity. Predictive and statistically significant models were generated
