5269-05-6

Basic information

• Product Name: 3-(N-Cyclohexylamino) phenol
• Synonyms: 3-(N-Cyclohexylamino) phenol;PHENOL,3-(CYCLOHEXYLAMINO)-;m-(Cyclohexylamino)phenol
• CAS NO: 5269-05-6
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 5269-05-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(N-Cyclohexylamino) phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-Cyclohexylamino) phenol(5269-05-6)
• EPA Substance Registry System: 3-(N-Cyclohexylamino) phenol(5269-05-6)

Safety Data

• Hazardous Substances Data: 5269-05-6(Hazardous Substances Data)

Usage

General Description

3-(N-Cyclohexylamino) phenol is a chemical compound that consists of a phenol group attached to a cyclohexylamino group at the 3-position. It is a colorless to light yellow solid with a molecular formula of C12H17NO. 3-(N-Cyclohexylamino) phenol is commonly used in the manufacturing of hair dyes, pigments, and other cosmetic products. It has been found to have antioxidant and antibacterial properties, making it useful in various personal care and pharmaceutical applications. Additionally, 3-(N-Cyclohexylamino) phenol has been studied for its potential as a corrosion inhibitor in metalworking fluids and as a dye in colorimetric assays. Overall, this compound has a range of industrial and scientific uses, and its properties make it an important ingredient in various products.

Upstream product

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Downstream Products

• 108-46-3 recorcinol 

Relevant articles and documents

NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.

Highly reactive, general and long-lived catalysts for palladium-catalyzed amination of heteroaryl and aryl chlorides, bromides, and iodides: Scope and structure-activity relationships

We describe a systematic study of the scope and relationship between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alkylphosphines for the amination of heteroaryl and aryl chlorides, bromides, and iodides. In the presence of this catalyst, aryl and heteroaryl chlorides, bromides, and iodides react with many primary amines in high yields with part-per-million quantities of palladium precursor and ligand. Many reactions of primary amines with both heteroaryl and aryl chlorides, bromides, and iodides occur to completion with 0.0005-0.05 mol % catalyst. A comparison of the reactivity of this catalyst for the coupling of primary amines at these loadings is made with catalysts generated from hindered monophosphines and carbenes, and these data illustrate the benefits of chelation. Studies on structural variants of the most active catalyst indicate that a rigid backbone in the bidentate structure, strong electron donation, and severe hindrance all contribute to its high reactivity. Thus, these complexes constitute a fourth-generation catalyst for the amination of aryl halides, whose activity complements catalysts based on monophosphines and carbenes.

Process for preparing N-alkylaminophenols

A process for preparing an N-alkylaminophenol is disclosed, comprising subjecting an aminophenol to reductive alkylation with an aldehyde or a ketone in the presence of an organic solvent and hydrogen, wherein the reductive alkylation is carried out at a temperature of from 20° to 70° C. in the further presence of a catalyst for reduction comprising platinum and at least one metal element selected from metal elements belonging to the IB group, IIB group, IVB group, VB group, and VIB group of the Periodic Table, supported on activated carbon, or comprising palladium and at least one metal element selected from metal elements belonging to the IB group, IIB group, IVB group, VB group and VIB group of the Periodic Table, supported on activated carbon.