52722-89-1

Basic information

• Product Name: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol
• Synonyms: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol
• CAS NO: 52722-89-1
• Molecular Weight: 277.407
• Mol File: 52722-89-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol(52722-89-1)
• EPA Substance Registry System: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol(52722-89-1)

Safety Data

• Hazardous Substances Data: 52722-89-1(Hazardous Substances Data)

Upstream product

• 101866-33-5 2-(4-hydroxy-2,2,6,6-tetramethyl-piperidino)-1-phenyl-ethanone 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 70-11-1 α-bromoacetophenone 
• 2403-88-5 4-hydroxy-2,2,6,6-tetramethylpiperidine 
• 96-09-3 styrene oxide 

Relevant articles and documents

General methodology for the chemoselective N-alkylation of (2,2,6,6)-tetramethylpiperidin-4-ol: Contribution of microwave irradiation

A convenient method to access a broad variety of N-alkyl-(2,2,6,6)-tetramethylpiperidin-4-ol compounds is reported. The thermal treatment of a mixture of (2,2,6,6)-tetramethylpiperidin-4-ol and allyl or benzyl bromide derivatives gave the corresponding N–alkylated compounds in good yields while leaving the hydroxyl functional group intact. Whereas 40 h were needed to reach complete conversion, microwave irradiation allowed the reaction time to be reduced (20 min) and improved the yields in most cases.