52727-44-3Relevant articles and documents
Ketoserin intermediate and preparation method of ketoserin
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, (2021/01/15)
The invention discloses a preparation method of a ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone and a preparation method of ketoserin, and the reaction equation of the preparation method of the ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone is shown in the specification: in the reaction, sodium carbonate and acetonitrile are used, no catalyst is added, inorganic salt is removed through hot filtration after the reaction, filtrate is evaporated to dryness, acetonitrile is recycled, and an intermediate 04, namely the ketoserin intermediate2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone, is obtained. The method is simple and convenient to operate, lower in cost, better in product character and more beneficial to synthesis of a finalproduct.
VMAT INHIBITORY COMPOUNDS
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Paragraph 0122-0123, (2016/04/01)
Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions.
Reactions of Anthranilamide with Isocyanates: A New Facile Synthesis of 2,3-Dihydro-5H-oxazoloquinazolin-5-one and 3,4-dihydro-2H,6H-oxazinoquinazolin-6-one
Chern, Ji-Wang,Shish, Fang-Jy,Chang, Chau-Dung,Chan, Chao-Han,Liu, Kang-Chien
, p. 1103 - 1105 (2007/10/02)
2,3-Dihydro-5H-oxazoloquinazolin-5-one 5a was synthesized from anthranilamide 1 and 2-chloroethyl isocyanate either by a direct reflux in methanol, or by stirring at room temperature in acetonitrile leading to the intermediate, 2-(2-chloroethyl ureido)benzamide 6a which was subsequently cyclized on heating with an organic base.However, when compound 6a was refluxed with concentrated hydrochloric acid, it furnished 3-(2-chloroethyl)-2,4-dioxo-1H,3H-quinazoline 2a in a good yields. 3,4-Dihydro-2H,6H-oxazinoquinazolin-6-one 5b, 3-(3-chloropropyl)-2,4-dioxo-1H,3H-quinazoline 2b and 2-(3-chloropropyl ureido)benzamide 6b were obtained similarly from 1 and 3-chloropropyl isocyanate.