52744-26-0 Usage
Description
Propyl 4-hydroxy-3-methoxyphenylacetate, also known as Homovanillic Acid Propyl Ester, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical agents. It is characterized by its ester functional group and aromatic structure, which contribute to its chemical properties and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Propyl 4-hydroxy-3-methoxyphenylacetate is used as an intermediate in the synthesis of Sombrevin (S676765), which is an anesthetic agent. Its role in the synthesis process is crucial for the development of effective anesthetics that can provide pain relief during medical procedures.
Used in Anesthetic Applications:
Propyl 4-hydroxy-3-methoxyphenylacetate contributes to the development of anesthetic agents, such as Sombrevin, which are used for their pain-relieving properties during medical and surgical procedures. propyl 4-hydroxy-3-methoxyphenylacetate's involvement in the synthesis of these agents highlights its importance in the field of anesthesiology and patient care.
Check Digit Verification of cas no
The CAS Registry Mumber 52744-26-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,4 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52744-26:
(7*5)+(6*2)+(5*7)+(4*4)+(3*4)+(2*2)+(1*6)=120
120 % 10 = 0
So 52744-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O4/c1-3-6-16-12(14)8-9-4-5-10(13)11(7-9)15-2/h4-5,7,13H,3,6,8H2,1-2H3
52744-26-0Relevant articles and documents
Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents
Qi, Zhaoyang,Li, Ziying,Zhu, Mo,Zhang, Xiaohua,Zhang, Guisen,Zhuang, Tao,Chen, Yin,Huang, Ling
, (2021/12/20)
In this paper, we designed and synthesized a series of novel phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents. The best compound 10 had relatively high affinity for the GABAA receptor and low affinity for thirteen other off-target receptors. In three animal models (mice, rats, and rabbits), compound 10 exerted potent hypnotic effects (HD50 = 5.2 mg/kg in rabbits), comparable duration of the loss of righting reflex (LORR), and significant shorter recovery time (time to walk) than propanidid. Furthermore, compound 10 (TI = 18.1) showed higher safety profile than propanidid (TI = 14.7) in rabbits. Above results suggested that compound 10 may have predictable and rapid recovery profile in anesthesia.
HOMOVANILLIC ESTER, MORE PARTICULARLY FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS
-
Paragraph 0195; 0196; 0213-0216, (2019/09/20)
Compounds of formula (I) and novel uses of compounds of formula (I), such as for flavour compositions. New preparations and new methods using compounds of formula (I).
Short-acting sedative hypnotic agents for anesthesia and sedation
-
, (2008/06/13)
The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
