52772-11-9

Basic information

• Product Name: ETHYL THIOSALICYLATE
• Synonyms: ETHYL THIOSALICYLATE;Benzenecarbothioic acid S-(2-hydroxyethyl) ester;S-2-Hydroxyethyl benzenecarbothioate;ethyl 2-sulfanylbenzoate
• CAS NO: 52772-11-9
• Molecular Formula: C₉H₁₀O₂S
• Molecular Weight: 182.2395
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 52772-11-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 298℃
• Flash Point: 134℃
• Appearance: /
• Density: 1.209
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.5942
• PKA: 14.13±0.10(Predicted)
• CAS DataBase Reference: ETHYL THIOSALICYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL THIOSALICYLATE(52772-11-9)
• EPA Substance Registry System: ETHYL THIOSALICYLATE(52772-11-9)

Safety Data

• Hazardous Substances Data: 52772-11-9(Hazardous Substances Data)

Usage

General Description

Ethyl thiosalicylate is a chemical compound with a molecular formula C9H10O2S. It is the ethyl ester of thiosalicylic acid and is commonly used as a fragrance ingredient in perfumes and personal care products. The compound has a sweet, fruity scent and is often used to add a fruity or berry-like note to fragrances. It is also used in the production of various flavor compounds for food and beverages. Ethyl thiosalicylate is considered safe for use in cosmetics and personal care products at low concentrations, but it can cause skin irritation and allergic reactions in some individuals at higher concentrations.

InChI:InChI=1/C9H10O2S/c1-2-11-9(10)7-5-3-4-6-8(7)12/h3-6,12H,2H2,1H3

Upstream product

• 75-21-8 oxirane 
• 98-91-9 thiobenzoic acid 
• 60759-50-4 3-acyl-2-oxazolone(R=Ph) 
• 60-24-2 2-hydroxyethanethiol 
• 618-32-6 Benzoyl bromide 
• 93-97-0 benzoic acid anhydride 
• 540-51-2 2-bromoethanol 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 98-91-9 thiobenzoic acid 
• 624-76-0 Iodoethanol 

Downstream Products

• 145803-43-6 (E)-3,3'-Dioxo-3H,3'H-[2,2']bi[benzo[b]thiophenylidene]-7,7'-dicarboxylic acid bis-(2-benzoylsulfanyl-ethyl) ester 
• 194612-85-6 bis(phenyl)S-acyl-2-thioethyl H-phosphonate 
• 1454611-85-8 N-3-tert-butoxycarbonyl-1-(6-deoxy-6-di(S-benzoylthio)ethylphosphono-2,3-O-isopropylidene-β-D-ribo-(5S)-hexofuranosyl)uracil 

Relevant articles and documents

One-pot synthesis of thioesters with sodium thiosulfate as a sulfur surrogate under transition metal-free conditions

In this paper, we report an efficient synthetic method for thioester formation from sodium thiosulfate pentahydrate, organic halides, and aryl anhydrides. In the one-pot two-step reactions developed in this study, sodium thiosulfate was used as the sulfur surrogate for acylation with anhydrides, followed by substitution with organic halides through the in situ generation of thioaroylate. Furthermore, two important organic compounds could be successfully synthesized using our developed method. The advantages of the one-pot two-step reactions are operational simplicity, structurally diverse products with 42%-90% yields, use of relatively low toxic and odourless reagents, and easy applicability to large-scale operation.

Effective esterification of carboxylic acids using (6-oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester as novel coupling agents

(6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl esters (3) are efficient and selective coupling agents for equimolar esterification of carboxylic acids and alcohols. Esterification of aliphatic and aromatic carboxylic acids with aliphatic and aromatic alcohols using 3 afforded the corresponding esters chemoselectively in good to excellent yield.

New prodrugs of 9-(2-phosphonomethoxyethyl) adenine [PMEA]: Synthesis and stability studies

The synthesis, and stability in different media of new PMEA prodrugs, with S-acyl-thioethyl (SATE) as enzyme-labile phosphonate protecting groups, are described in comparison with the already known Bis(POM)- and Bis(DTE)PMEA.