52779-71-2Relevant articles and documents
Efficient and ecofriendly protocol for tetrahydropyranylation/ depyranylation of alcohols in the presence of tin(II) chloride dihydrate
Gogoi, Dipankoj,Baruah, Nabajyoti,Bez, Ghanashyam
, p. 595 - 599 (2007)
A mild, efficient, and solvent-free protocol for tetrahydropyranylation of alcohols in the presence of a catalytic amount of SnCl2·2H2O is reported. Simple filtration of the reaction mixture through a short silica-gel pad gives the pure products in excellent yields. Depyranylation can also be achieved by adding methanol under similar reaction conditions. Copyright Taylor & Francis Group, LLC.
Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives
van Daele,Boey,Sipido,De Bruyn,Janssen
, p. 1495 - 1501 (2007/10/05)
A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.
