5279-59-4

Basic information

• Product Name: (4-tert-Butyl-phenyl)-Methyl-aMine
• Synonyms: (4-tert-Butyl-phenyl)-Methyl-aMine
• CAS NO: 5279-59-4
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.25938
• EINECS: -0
• Mol File: 5279-59-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-tert-Butyl-phenyl)-Methyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-tert-Butyl-phenyl)-Methyl-aMine(5279-59-4)
• EPA Substance Registry System: (4-tert-Butyl-phenyl)-Methyl-aMine(5279-59-4)

Safety Data

• Hazardous Substances Data: 5279-59-4(Hazardous Substances Data)

Usage

Description

(4-tert-Butyl-phenyl)-Methyl-aMine, also known as a derivative of aniline, is a chemical compound characterized by a tert-butyl substituted phenyl group and a methyl group. It is a clear liquid with a strong amine odor and is recognized for its applications in the pharmaceutical and agrochemical industries. Due to its chemical structure, it serves as a crucial intermediate for the synthesis of other organic compounds, making it a valuable asset in research and industrial settings.

Uses

Used in Pharmaceutical Industry:
(4-tert-Butyl-phenyl)-Methyl-aMine is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the creation of a wide range of products with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (4-tert-Butyl-phenyl)-Methyl-aMine is utilized as a building block for the development of new compounds with pesticidal, herbicidal, or fungicidal properties. Its versatility in chemical reactions contributes to the creation of innovative solutions for agricultural challenges.
Used in Organic Synthesis:
(4-tert-Butyl-phenyl)-Methyl-aMine is used as an intermediate in the synthesis of other organic compounds. Its reactivity and structural features make it a valuable component in the development of new molecules with diverse applications, including those in the fields of materials science, chemical engineering, and specialty chemicals.

Upstream product

• 63429-97-0 N-(4-(tert-butyl)phenyl)formamide 
• 253185-03-4 tert-butylbenzene 
• 25370-97-2 O-(p-toluenesulfonyl)-N-methylhydroxylamine 
• 769-92-6 4-tert-Butylaniline 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 616-38-6 carbonic acid dimethyl ester 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 1943-67-5 4-(t-butyl)phenyl isocyanate 
• 2909-79-7 4-tert-butyl-N,N-dimethylaniline 

Downstream Products

• 1403475-52-4 N-[4-(tert-butyl)phenyl]-N-methylmethacrylamide 
• 114833-70-4 N-[4-(1,1-Dimethylethyl)phenyl]-N-methyl-5-methylisoxazol-4-ylcarboxamide 

Relevant articles and documents

Photoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes

Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene functionalization. Herein, we demonstrated that aryl radicals generated from electron-deficient aryl chlorides/bromides could be trapped by an array of terminal/internal aryl alkenes in the presence of [Pt(O^N^C^N)] under visible-light (410 nm) irradiation, affording anti-Markovnikov hydroarylated compounds in up to 95 % yield. Besides, a protocol for [Pt(O^N^C^N)]-catalyzed intramolecular photocyclization of acrylanilides to give structurally diverse 3,4-dihydroquinolinones has been developed.

Ruthenium(ii) complexes with N-heterocyclic carbene-phosphine ligands for theN-alkylation of amines with alcohols

Metal hydride complexes are key intermediates forN-alkylation of amines with alcohols by the borrowing hydrogen/hydrogen autotransfer (BH/HA) strategy. Reactivity tuning of metal hydride complexes could adjust the dehydrogenation of alcohols and the hydrogenation of imines. Herein we report ruthenium(ii) complexes with hetero-bidentate N-heterocyclic carbene (NHC)-phosphine ligands, which realize smart pathway selection in theN-alkylated reactionviareactivity tuning of [Ru-H] species by hetero-bidentate ligands. In particular, complex6cbwith a phenyl wingtip group and BArF?counter anion, is shown to be one of the most efficient pre-catalysts for this transformation (temperature is as low as 70 °C, neat conditions and catalyst loading is as low as 0.25 mol%). A large variety of (hetero)aromatic amines and primary alcohols were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields. Notably, aliphatic amines, challenging methanol and diamines could also be transformed into the desired products. Detailed control experiments and density functional theory (DFT) calculations provide insights to understand the mechanism and the smart pathway selectionvia[Ru-H] species in this process.

Room temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols

The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcohols by a bis-NHC manganese complex is presented. This system was applied to a large range of alcohols and anilines, including biologically relevant motifs and challenging methanol. Experimental and computational studies suggest an outer-sphere mechanism for this NHC-Mn system.