52807-31-5

Basic information

• Product Name: Benzenecarboximidoyl chloride, N-(3-methylphenyl)-
• CAS NO: 52807-31-5
• Molecular Formula: C14H12ClN
• Molecular Weight: 229.709
• Mol File: 52807-31-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidoyl chloride, N-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidoyl chloride, N-(3-methylphenyl)-(52807-31-5)
• EPA Substance Registry System: Benzenecarboximidoyl chloride, N-(3-methylphenyl)-(52807-31-5)

Safety Data

• Hazardous Substances Data: 52807-31-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 108-44-1 1-amino-3-methylbenzene 
• 582-77-4 3'-methylbenzanilide 

Downstream Products

• 37856-15-8 2-phenyl-3-(m-tolyl)quinazolin-4(3H)-one 
• 66354-87-8 6-methyl-2-phenyl-1H-indole 
• 666723-12-2 N-(1-phenyl-2-propyn-1-ylidene)-3-methylbenzenamine 
• 1428326-96-8 4-methyl-N-(2-phenyl-5-methyl-4-quinolinyl)-benzenesulfonamide 
• 1207847-65-1 (5-methyl-2-phenylquinolin-4-yl)(phenyl)methanone 
• 73333-80-9 N-(3-Methylphenyl)-N-phenylbenzamide 
• 1205-64-7 3-Methyldiphenylamine 
• 98888-82-5 2,4-Bis(N-ethoxythiocarbonyl-m-toluidino)-2,4-diphenyl-1,3-dithietan 
• 666175-16-2 1-ethyl-3-[(phenyl)-(3-tolylimino)methyl]thiourea 
• 666175-08-2 1-methyl-3-[(phenyl)-(3-tolylimino)methyl]thiourea 
• 425366-05-8 N-m-tolyl-benzimidic acid 4-cyano-phenyl ester 
• 98888-74-5 Thiobenzoyl-m-tolyl-thiocarbamic acid O-ethyl ester 
• 52411-68-4 1-(m-tolyl)-5-phenyltetrazole 

Relevant articles and documents

Synthesis of Imidoyl Chlorides Using Phosphorus Trichloride

Abstract: The reaction of carboxamides with phosphorus trichloride under heating at 75–80°C for 1 h in the presence of a 4-dimethylaminopyridine catalyst was used to synthesize imidoyl chlorides in yields of 63–99%.

α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles

Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).

Synthesis and Biological Evaluation of 2,3,5-Substituted [1,2,4]Thiadiazoles as Allosteric Modulators of Adenosine Receptors

A number of 2,3,5-substituted [1,2,4]thiadiazole analogues of SCH-202676 (N-(2,3-diphenyl-[1,2,4]thiadiazole-5(2H)-ylidene)methanamine, 7a) were synthesized and tested as potential allosteric modulators of adenosine receptors. All compounds were capable of displacing the binding of the radiolabeled agonist [3H]CCPA to human A1 adenosine receptors, whereas modest and varying effects were observed on the binding of [3H]DPCPX, a radiolabeled antagonist for this receptor subtype. Four compounds, 7a (SCH-202676), 7k (LUF5792), 71 (LUF5794), and 8e (LUF5789), were selected for more detailed characterization. They all proved allosteric inhibitors of agonist binding, with 7k being most potent, whereas their effects on antagonist binding were more ambiguous. Subsequently, experiments were done on human adenosine A2A and A3 receptors. Compounds 7a and 7l displayed peculiar displacement characteristics of both radiolabeled agonist and antagonist binding to A2A receptors, whereas 7a showed some activity on A3 receptors.