5281-28-7

Basic information

• Product Name: Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo-
• CAS NO: 5281-28-7
• Molecular Formula: C15H6Br4F6O2
• Molecular Weight: 651.818
• Mol File: 5281-28-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo-(5281-28-7)
• EPA Substance Registry System: Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo-(5281-28-7)

Safety Data

• Hazardous Substances Data: 5281-28-7(Hazardous Substances Data)

Usage

General Description

Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo- is a complex chemical compound that contains phenol and 2,6-dibromo- along with a unique trifluoro-1-(trifluoromethyl)ethylidene group. Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromo- is characterized by its strong disinfectant properties due to the presence of the bromine and fluorine atoms. It is commonly used in various industrial applications such as in the production of pesticides, flame retardants, and pharmaceuticals. However, due to its toxic nature, it is important to handle this chemical with caution and follow proper safety procedures when using it in any application.

Upstream product

• 1478-61-1 4,4'-(hexafluoroisopropylidene)diphenol 

Downstream Products

• 1239516-69-8 2,2'-(4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromo-4,1-phenylene))bis(oxy)bis(methylene)dioxirane 
• 910571-52-7 C₃₇H₂₂Br₄N₂O₈ 

Relevant articles and documents

Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-amyloid peptide aggregation inhibitors

The aggregation of A? is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A? undergoes ?-helix/?-sheet intermediate structures during the conformational transition, and an A? aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A? but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A? 1?42-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.