52841-36-8

Basic information

• Product Name: 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester
• Synonyms: 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester
• CAS NO: 52841-36-8
• Molecular Weight: 274.34
• Mol File: 52841-36-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester(52841-36-8)
• EPA Substance Registry System: 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester(52841-36-8)

Safety Data

• Hazardous Substances Data: 52841-36-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 40828-46-4 2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid 
• 52779-97-2 p-(2-thenoyl)hydratropic acid, sodium salt 
• 108-20-3 di-isopropyl ether 
• 74-88-4 methyl iodide 
• 67333-53-3 Methyl α-methylthio-α-[p-(2-thienylcarbonyl)-phenyl]propionate 
• 5188-07-8 sodium thiomethoxide 
• 1003-09-4 2-bromothiophene 
• 201230-82-2 carbon monoxide 
• 2156-04-9 4-Vinylphenylboronic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 52779-83-6 [4-(1-bromoethyl)phenyl]-2-thienyl ketone 
• 52841-34-6 p-(1-chloroethyl)phenyl thien-2-yl ketone 
• 52841-35-7 (4-bromomethyl-phenyl)-thiophen-2-yl-methanone 

Downstream Products

• 52780-12-8 (S)-Suprofen 
• 81601-94-7 (R)-suprofen methyl ester 

Relevant articles and documents

An efficient and practical sequential one-pot synthesis of suprofen, ketoprofen and other 2-arylpropionic acids

A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.

Novel α-thio-alkanoic acid derivatives

Novel α-thio-alkanoic acid derivatives and a process for their preparation. These novel compounds can be easily converted to useful medicines.

Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives

A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.