528839-31-8

Basic information

• Product Name: (6R,7R)-7-[2-(4-tert-Butoxycarbonyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• Synonyms: (6R,7R)-7-[2-(4-tert-Butoxycarbonyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS NO: 528839-31-8
• Molecular Weight: 734.121
• Mol File: 528839-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R,7R)-7-[2-(4-tert-Butoxycarbonyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-7-[2-(4-tert-Butoxycarbonyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(528839-31-8)
• EPA Substance Registry System: (6R,7R)-7-[2-(4-tert-Butoxycarbonyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(528839-31-8)

Safety Data

• Hazardous Substances Data: 528839-31-8(Hazardous Substances Data)

Upstream product

• 208512-54-3 2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzoic acid tert-butyl ester 
• 208512-53-2 2,4,5-trichloro-benzoic acid tert-butyl ester 
• 50-82-8 2,4,5-trichlorobenzoic acid 
• 35696-87-8 2,4,5-trichlorobenzaldehyde 
• 415926-78-2 4-carboxymethylsulfanyl-2,5-dichloro-benzoic acid tert-butyl ester 

Downstream Products

• 528839-32-9 (6R,7R)-7-[2-(4-Carboxy-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant articles and documents

Anti-MRSA cephems. Part 3: additional C-7 acid derivatives.

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC(90) against MRSA of 3.7 microg/mL, and an average PD(50) of 3.9 mg/kg.