52916-86-6

Basic information

• Product Name: 2,3-dibromo-3-p-tolyl-propionic acid
• Synonyms: 2,3-dibromo-3-p-tolyl-propionic acid
• CAS NO: 52916-86-6
• Molecular Weight: 321.996
• Mol File: 52916-86-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2,3-dibromo-3-p-tolyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dibromo-3-p-tolyl-propionic acid(52916-86-6)
• EPA Substance Registry System: 2,3-dibromo-3-p-tolyl-propionic acid(52916-86-6)

Safety Data

• Hazardous Substances Data: 52916-86-6(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 1866-39-3 trans-p-methylcinnamic acid 
• 1866-39-3 4-methylcinnamic acid 

Downstream Products

• 62849-00-7 p-Tolyl-propynoyl chloride 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 1607020-74-5 N-(4-methylphenyl)-3-exo-4-methylbenzylidenetricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 1607020-86-9 3-exo-(4-methylbenzylidene)tricyclo[3.2.1.02,4]octane 
• 1607020-82-5 N-isobutyl-3-exo-(4-methylbenzylidene)tricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 766-97-2 4-n-methylphenylacetylene 
• 5301-96-2 4-(p-tolyl)-1H-[1,2,3]triazole 
• 87212-87-1 (1Z,3Z)-1,4-di-p-tolylbuta-1,3-diene 
• 14290-88-1 (2Z)-3-(4-methylphenyl)propenoic acid 
• 93501-03-2 2,3-Dibromo-3-p-tolyl-thiopropionic acid S-p-tolyl ester 
• 93500-99-3 2,3-Dibromo-3-p-tolyl-propionic acid p-tolyl ester 

Relevant articles and documents

Palladium-Catalyzed Two-Component Domino Coupling Reaction of (Z)-β-Bromostyrenes with Norbornenes: Synthesis of 1,5-Enynes

Polyfunctional molecules, 1,5-enynes, have been achieved via a palladium(0)-catalyzed domino coupling reaction of (Z)-β-bromostyrenes with norbornenes in the presence of cesium carbonate and N,N-dimethylformamide. The process involves a double Heck-type procedure, two-fold C(sp2) H activation and formation of two carbon-carbon bonds. There are possibilities of diversified transformation for the domino coupling of (Z)-β-bromostyrenes with norbornenes, the procedure is successfully driven to 1,5-enynes via accurate adjustment of the reaction conditions. (Figure presented.) .

A Facile Access to trans -3-Styryl-4-hydrazinocyclopentenes via Palladium-Catalyzed Ring Opening of Diazanorbornenes with (Z)-β-Bromostyrenes/2,3-Dibromohydrocinnamic Acids

trans -3-Styryl-4-hydrazinocyclopentenes have been synthesized via palladium-catalyzed desymmetrization of diazanorbornenes with (Z)-β-bromostyrenes. The reaction also works well with (Z)-β-bromostyrenes generated in situ from 2,3-dibromohydrocinnamic acids. The synthesized hydrazinocyclopentenes provide an easy route towards synthetic intermediates of many scaffolds of biological potential.

Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study

An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.