52938-98-4

Basic information

• Product Name: 5-(4-METHYLPHENYL)-2-FUROIC ACID
• Synonyms: CHEMBRDG-BB 4401948;5-P-TOLYL-FURAN-2-CARBOXYLIC ACID;AKOS BAR-0046;5-(4-METHYLPHENYL)-2-FUROIC ACID;5-(4-Tolyl)-furane-2-carboxylic acid;5-(4-methylphenyl)-2-furoic acid(SALTDATA: FREE);5-(4-Methylphenyl)furan-2-carboxylic acid, 2-Carboxy-5-(4-methylphenyl)furan, 4-(5-Carboxyfur-2-yl)toluene;5-(4-Methylphenyl)-2-furoic acid 97%
• CAS NO: 52938-98-4
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Product Categories: Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 52938-98-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 179-181 °C(lit.)
• Boiling Point: 374.6 °C at 760 mmHg
• Flash Point: 180.4 °C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 2.81E-06mmHg at 25°C
• Refractive Index: 1.574
• PKA: 3.21±0.10(Predicted)
• CAS DataBase Reference: 5-(4-METHYLPHENYL)-2-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHYLPHENYL)-2-FUROIC ACID(52938-98-4)
• EPA Substance Registry System: 5-(4-METHYLPHENYL)-2-FUROIC ACID(52938-98-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 52938-98-4(Hazardous Substances Data)

Usage

General Description

5-(4-Methylphenyl)-2-furoic acid is a chemical compound with the molecular formula C13H10O3. It is a white crystalline solid with a molecular weight of 214.21 g/mol. 5-(4-METHYLPHENYL)-2-FUROIC ACID is a derivative of furoic acid and contains a methylphenyl group. It is used in pharmaceutical and organic synthesis as a building block for the production of various compounds. The presence of the furoic acid moiety in its structure gives it potential biological activities, making it an interesting target for pharmacological studies. 5-(4-Methylphenyl)-2-furoic acid is also used as a reference standard in analytical chemistry for its identification and quantification in various samples.

InChI:InChI=1/C12H10O3/c1-8-2-4-9(5-3-8)10-6-7-11(15-10)12(13)14/h2-7H,1H3,(H,13,14)

Upstream product

• 88-14-2 2-furanoic acid 
• 106-49-0 p-toluidine 
• 34035-05-7 5-(4-tolyl)-2-furaldehyde 
• 52939-04-5 5-(4-methylphenyl)furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 1370724-45-0 2-deutero-5-(p-tolyl)furan 
• 1365714-62-0 3,4,5-triethoxybenzyl 5-(4-methylphenyl)-2-furoate 
• 1365714-54-0 3,4,5-trimethoxybenzyl 5-(4-methylphenyl)-2-furoate 
• 1354698-33-1 N-5-(4'-methylphenyl)-2-furoyl-1H-1,2,4-triazole 
• 1354698-22-8 N-5-(4'-methylphenyl)-2-furoyl-1H-pyrazole 
• 1323991-18-9 3-{4-[5-(4-tert-butoxycarbonylamino-phenyl)-[1,2,4]oxadiazol-3-yl]-3-fluoro-phenyl}-2-[(5-p-tolyl-furan-2-carbonyl)-amino]-propionic acid 
• 1323995-32-9 5-[5-(4-tert-butoxycarbonylamino-phenyl)-[1,2,4]oxadiazol-3-yl]-2-[(5-p-tolyl-furan-2-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester 
• 1323995-23-8 5-bromo-2-[ (5-p-tolyl-furan-2-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester 
• 1323994-79-1 3-{4-[5-(4-tert-butoxycarbonylamino-phenyl)-[1,2,4]oxadiazol-3-yl]-3-fluorophenyl}-2-[(5-p-tolyl-furan-2-carbonyl)amino]-propionic acid ethyl ester 

Relevant articles and documents

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important