529508-54-1

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)
• Synonyms: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI);4-Hydroxy-5-Methylpyrrolo[1,2-f][1,2,4] triazine;5-Methylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one;4-Hydroxy-5-Methylpyrrolo...;5-Methylpyrrolo[2,1-f][1,2,4]triazin-4(1H)-one;5-Methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one;5-methyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one;5-methylpyrrolo[2,1-f][1,2,4]triazin-4-ol
• CAS NO: 529508-54-1
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.152
• Product Categories: ALCOHOL
• Mol File: 529508-54-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.42
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)(529508-54-1)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)(529508-54-1)

Safety Data

• Hazardous Substances Data: 529508-54-1(Hazardous Substances Data)

Usage

General Description

Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI) is a chemical compound with the molecular formula C6H5N3O. It belongs to the class of organic compounds known as pyrrolo[2,1-f][1,2,4]triazin-4(1H)-ones. Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI) is a derivative of pyrrolo[2,1-f][1,2,4]triazine, which is a polycyclic aromatic hydrocarbon. It is commonly used in pharmaceutical and agrochemical industries for the synthesis of bioactive molecules. The 5-methyl substitution on the pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one ring gives it specific properties and potential applications in drug discovery and development. Its chemical structure and properties make it an important compound for further research and exploration in the fields of medicinal chemistry and chemical biology.

Upstream product

• 616-43-3 3-methylpyrrole 
• 1392140-56-5 ethyl 1-amino-3-methyl-1H-pyrrole-2-carboxylate 
• 463-52-5 formamidine 
• 3284-47-7 ethyl 3-methyl-1H-pyrrole-2-carboxylate 
• 310435-15-5 C₈H₇N₃O₃ 
• 427878-70-4 ethyl 4-hydroxy-5-methylpyrrolo[2,1-f ][1,2,4]-triazine-6-carboxylate 
• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 77287-34-4 formamide 
• 310435-15-5 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 310431-29-9 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310430-89-8 1-amino-3-methyl-1H-pyrrole-2-carbonitrile 
• 64-18-6 formic acid 
• 310436-79-4 1-amino-2-aminocarbonyl-3-methylpyrrole 

Downstream Products

• 529508-56-3 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 859205-88-2 5-methyl-4-(methylthio)pyrrolo[2,1-f][1,2,4]triazine 

Relevant articles and documents

PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF

The present invention relates to a group of pyrrolo[2, 1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

PYRROLOTRIAZINE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template

The pyrrolo[2,1-f][1,2,4]triazine nucleus was identified as a novel kinase inhibitor template which effectively mimics the well-known quinazoline kinase inhibitor scaffold. Attachment of a 4-((3-chloro-4-fluorophenyl)amino) substituent to the template provided potent biochemical inhibitors of the tyrosine kinase activity of EGFR, as well as inhibition of cellular proliferation of the human colon tumor cell line DiFi. Attachment of a 4-((3-hydroxy-4-methylphenyl)amino) substituent provided potent inhibitors of VEGFR-2 which also showed effects on the VEGF-dependent proliferation of human umbilical vein endothelial cells. Biological activity was maintained with substitution at positions 5 or 6, but not 7, suggesting that the former positions are promising sites for introducing side chains which modulate physicochemical. properties. Preliminary inhibition studies with varying ATP concentrations suggest that, like the quinazoline-based kinase inhibitors, the pyrrolotriazine-based inhibitors bind in the ATP pocket.