52980-68-4 Usage
Description
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID is a chemical compound with the potential to inhibit human DNA methyltransferase, which plays a crucial role in the regulation of gene expression and is often dysregulated in various diseases, including cancer.
Uses
Used in Pharmaceutical Industry:
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID is used as an inhibitor for human DNA methyltransferase to regulate gene expression and potentially treat diseases associated with abnormal methylation patterns, such as cancer.
Used in Cancer Research:
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID is used as a research tool to study the role of DNA methylation in cancer development and progression, aiding in the discovery of novel therapeutic strategies targeting this epigenetic modification.
Check Digit Verification of cas no
The CAS Registry Mumber 52980-68-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,9,8 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52980-68:
(7*5)+(6*2)+(5*9)+(4*8)+(3*0)+(2*6)+(1*8)=144
144 % 10 = 4
So 52980-68-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2O5/c1-14-9-4-2-8(3-5-9)12(18)15-10(13(19)20)6-7-11(16)17/h2-5,10,14H,6-7H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t10-/m0/s1
52980-68-4Relevant articles and documents
Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer
Hirakawa, Kazutaka,Aoshima, Masahiro,Hiraku, Yusuke,Kawanishi, Shosuke
, p. 467 - 472 (2002)
Methotrexate (MTX), an antineoplastic agent, demonstrates phototoxicity. The mechanism of damage to biomacromolecules induced by photoirradiated MTX was examined using 32P-labeled DNA fragments obtained from a human gene. Photoirradiated MTX ca
Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid
Luo, Jin,Smith, Michael D.,Lantrip, Douglas A.,Wang, Susan,Fuchs
, p. 10004 - 10013 (2007/10/03)
Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.