530115-96-9

Basic information

• Product Name: 1-BOC-4-CYANO-4-METHYL-PIPERIDINE
• Synonyms: 1-BOC-4-CYANO-4-METHYL-PIPERIDINE;4-Cyano-4-methyl-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-cyano-4-Methylpiperidine-1-carboxylate;1-Boc-4-cyano-4-Methylpip...;Ert-Butyl 4-Cyano-4-Methylpiperidine-1-Carboxylate
• CAS NO: 530115-96-9
• Molecular Formula: C₁₂H₂₀N₂O₂
• Molecular Weight: 224.302
• Mol File: 530115-96-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 327.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.05±0.40(Predicted)
• CAS DataBase Reference: 1-BOC-4-CYANO-4-METHYL-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-CYANO-4-METHYL-PIPERIDINE(530115-96-9)
• EPA Substance Registry System: 1-BOC-4-CYANO-4-METHYL-PIPERIDINE(530115-96-9)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 530115-96-9(Hazardous Substances Data)

Usage

General Description

1-BOC-4-CYANO-4-METHYL-PIPERIDINE is a scientific compound that belongs to the class of organic compounds known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. The 1-BOC-4-CYANO-4-METHYL-PIPERIDINE compound carries a cyano group, a functional group consisting of a carbon atom triple-bonded to a nitrogen atom. It also carries a BOC, or tert-butyloxycarbonyl, group, which is a protecting group used in organic synthesis. The compound's molecular formula is C12H20N2O2, and it is also known by its IUPAC name, ((tert-Butoxycarbonyl)(4-cyano-4-methylpiperidin-1-yl)methanone.

InChI:InChI=1S/C12H20N2O2/c1-11(2,3)16-10(15)14-7-5-12(4,9-13)6-8-14/h5-8H2,1-4H3

Upstream product

• 343788-67-0 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 407-25-0 trifluoroacetic anhydride 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 74-88-4 methyl iodide 

Downstream Products

• 343788-67-0 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 948894-26-6 4-methylpiperidine-4-carbonitrile hydrochloride 
• 1257301-28-2 4-methylpiperidine-4-carboxamide hydrochloride 
• 948894-28-8 8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[({4-methyl-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one 
• 948894-30-2 8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-methyl-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one 
• 948894-29-9 1-{4-methyl-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methanamine 
• 948894-27-7 4-methyl-1-[2-(2-phenylethoxy)ethyl]piperidine-4-carbonitrile 
• 236406-22-7 tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate 
• 1037792-97-4 4-[4-(4-methanesulfonylphenoxymethyl)thiazol-2-yl]-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 951745-01-0 4-methyl-4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Protein Modification at Tyrosine with Iminoxyl Radicals

Post-translational modifications (PTMs) of proteins are a biological mechanism for reversibly controlling protein function. Synthetic protein modifications (SPMs) at specific canonical amino acids can mimic PTMs. However, reversible SPMs at hydrophobic amino acid residues in proteins are especially limited. Here, we report a tyrosine (Tyr)-selective SPM utilizing persistent iminoxyl radicals, which are readily generated from sterically hindered oximes via single-electron oxidation. The reactivity of iminoxyl radicals with Tyr was dependent on the steric and electronic demands of oximes; isopropyl methyl piperidinium oxime 1f formed stable adducts, whereas the reaction of tert-butyl methyl piperidinium oxime 1o was reversible. The difference in reversibility between 1f and 1o, differentiated only by one methyl group, is due to the stability of iminoxyl radicals, which is partly dictated by the bond dissociation energy of oxime O-H groups. The Tyr-selective modifications with 1f and 1o proceeded under physiologically relevant, mild conditions. Specifically, the stable Tyr-modification with 1f introduced functional small molecules, including an azobenzene photoswitch, to proteins. Moreover, masking critical Tyr residues by SPM with 1o, and subsequent deconjugation triggered by the treatment with a thiol, enabled on-demand control of protein functions. We applied this reversible Tyr modification with 1o to alter an enzymatic activity and the binding affinity of a monoclonal antibody with an antigen upon modification/deconjugation. The on-demand ON/OFF switch of protein functions through Tyr-selective and reversible covalent-bond formation will provide unique opportunities in biological research and therapeutics.

2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

INDUCTION OF GATA2 BY HDAC1 AND HDAC2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with Gata2 deficiency, particularly diseases or disorders that involve any type of HDAC1 and/or HDAC2 expression. Such diseases include acute myeloid leukemia (AML); familial myelodysplastic syndrome (MDS); leukemia; sickle-cell anemia; beta-thalassemia; monocytopenia and mycobacterial infections; dendritic cell, nonocyte, B, and natural killer lymphoid deficiency; Emberger syndrome; asymptomatic neurocognitive impairment; mild neurocognitive disorder; and HIV- associated dementia.