530116-33-7

Basic information

• Product Name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
• Synonyms: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
• CAS NO: 530116-33-7
• Molecular Formula: C₁₃H₂₆N₂O₂
• Molecular Weight: 242.35774
• Mol File: 530116-33-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 320.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.017±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.35±0.25(Predicted)
• CAS DataBase Reference: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine(530116-33-7)
• EPA Substance Registry System: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine(530116-33-7)

Safety Data

• Hazardous Substances Data: 530116-33-7(Hazardous Substances Data)

Usage

Description

4-(2-Aminopropan-2-yl)-1-Boc-piperidine is a chemical compound with the formula C14H26N2O2. It is a piperidine derivative that contains a Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom. 4-(2-Aminopropan-2-yl)-1-Boc-piperidine is known for its versatility in organic synthesis and its role as a building block for the preparation of various pharmaceuticals and biologically active molecules.

Uses

Used in Pharmaceutical Industry:
4-(2-Aminopropan-2-yl)-1-Boc-piperidine is used as a key intermediate for the synthesis of complex organic compounds and pharmaceuticals. Its structure and functional groups make it a valuable tool in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(2-Aminopropan-2-yl)-1-Boc-piperidine is used as a versatile building block for the preparation of a wide range of biologically active molecules. The presence of the Boc protecting group allows for selective reactions and manipulation of the molecule, facilitating the synthesis of complex organic compounds.

Upstream product

• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 917-54-4 methyllithium 

Downstream Products

• 1350916-78-7 N-[2-[4-(1-amino-1-methylethyl)-1-piperidinyl]-3-fluorophenyl]-4-(2-methyl-4-pyridinyl)-1H-imidazole-2-carboxamide 
• 1350918-32-9 N-(2-(4-(2-aminopropan-2-yl)piperidin-1-yl)-3-fluorophenyl)-4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide 
• 1350918-30-7 benzyl (2-(1-(2-amino-6-fluorophenyl)piperidin-4-yl)propan-2-yl)carbamate 
• 1350918-29-4 benzyl (2-(1-(2-fluoro-6-nitrophenyl)piperidin-4-yl)propan-2-yl)carbamate 
• 1057260-89-5 benzyl (2-(piperidin-4-yl)propan-2-yl)carbamate 
• 871730-81-3 tert-butyl 4-(2-(benzyloxycarbonylamino)propan-2-yl)piperidine-1-carboxylate 

Relevant articles and documents

Non-cryogenic CeCl3-promoted double additions of methyllithium and n-butyllithium to unsaturated nitriles

Subjection of methyl or n-butyllithium to a mixture of nitriles and activated cerium chloride in THF at -10 to 0 °C afforded the corresponding carbinamines, which were isolated as either the hydrochloride salts or acetamide or benzamide derivatives in 30-91% yields. Georg Thieme Verlag Stuttgart.