530141-40-3

Basic information

• Product Name: 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
• Synonyms: 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE;2-Bromo-2'-(trifluoromethoxy)acetophenone, 2-Bromo-1-[2-(trifluoromethoxy)phenyl]ethan-1-one;2-Bromo-1-(2-(trifluoromethoxy)phenyl)ethanone;2-(Trifluoromethoxy)phenacylbromide97%;2-bromo-1-[2-(trifluoromethoxy)phen
• CAS NO: 530141-40-3
• Molecular Formula: C₉H₆BrF₃O₂
• Molecular Weight: 283.04
• Mol File: 530141-40-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 52/0.04mm
• Appearance: /
• Density: 1.621±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE(530141-40-3)
• EPA Substance Registry System: 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE(530141-40-3)

Safety Data

• Hazard Codes: C
• HazardClass: CORROSIVE
• Hazardous Substances Data: 530141-40-3(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethoxy)phenacyl bromide is a chemical compound with the formula C10H8BrF3O. It is a phenacyl bromide derivative with a trifluoromethoxy group attached to the phenyl ring, and it is commonly used as a reagent for the synthesis of various organic compounds. It is a solid, colorless to light yellow substance that is soluble in organic solvents such as acetone, ether, and dichloromethane. 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE is often used as a reagent in organic synthesis, particularly in the preparation of novel pharmaceutical and agrochemical products due to its versatile chemical reactivity and stability. Additionally, it is also utilized in the development of new materials and chemical processes in the fields of organic chemistry and pharmaceutical research.

Upstream product

• 220227-93-0 1-(2-(trifluoromethoxy)phenyl)ethan-1-one 

Downstream Products

• 868851-38-1 3-oxo-2-[2-oxo-2-(2-trifluoromethoxy-phenyl)-ethyl]-butyric acid methyl ester 
• 1015756-71-4 C₁₂H₇F₃N₂OS 

Relevant articles and documents

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et al., 2015; Wang et al., 2012), depends on the activating ligand. A high-throughput screen identified two structurally distinct TPC2 agonists. One of these evoked robust Ca2+-signals and non-selective cation currents, the other weaker Ca2+-signals and Na+-selective currents. These properties were mirrored by the Ca2+- mobilizing messenger, NAADP and the phosphoinositide, PI(3,5)P2, respectively. Agonist action was differentially inhibited by mutation of a single TPC2 residue and coupled to opposing changes in lysosomal pH and exocytosis. Our findings resolve conflicting reports on the permeability and gating properties of TPC2 and they establish a new paradigm whereby a single ion channel mediates distinct, functionally-relevant ionic signatures on demand.

Thiadiazinones

Compounds of formula I STR1 in which R1 and R2 are each independently of one another H or A, R3 is H, OA or O--Cm H2m+1-n Xn, R4 is --O--Cm H2m+1-n Xn, X is F or Cl, A is alkyl having 1-6 C atoms, m is 1, 2, 3, 4, 5 or 6 and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, and their salts have positive ionitropic activity and vasodilating action, and promote circulation. In addition, the compounds can be employed for the treatment of asthmatic disease and memory disorders, and have anti-depressive and anti-inflammatory properties.