53117-14-9

Basic information

• Product Name: Ethyl [(2-methylphenyl)amino](oxo)acetate
• Synonyms: Ethyl [(2-methylphenyl)amino](oxo)acetate;2-[(2-methylphenyl)amino]-2-oxoacetic acid ethyl ester;2-keto-2-[(2-methylphenyl)amino]acetic acid ethyl ester;Acetic acid, [(2-methylphenyl)amino]oxo-, ethyl ester;AIDS135583;AIDS-135583;ethyl 2-[(2-methylphenyl)amino]-2-oxoacetate;ethyl 2-[(2-methylphenyl)amino]-2-oxo-acetate
• CAS NO: 53117-14-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 53117-14-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl [(2-methylphenyl)amino](oxo)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl [(2-methylphenyl)amino](oxo)acetate(53117-14-9)
• EPA Substance Registry System: Ethyl [(2-methylphenyl)amino](oxo)acetate(53117-14-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53117-14-9(Hazardous Substances Data)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 95-53-4 o-toluidine 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 1620231-50-6 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanamine 
• 1620231-49-3 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone oxime 
• 1620231-48-2 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone 
• 1620231-47-1 ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylate 
• 1620231-46-0 ethyl 2-chloro-2-(o-tolylimino)acetate 
• 1338471-38-7 (S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid 
• 406190-09-8 N-(o-tolyl)-oxamic acid 
• 875845-16-2 benzilic acid-(4-bromo-2-methyl-anilide) 
• 67241-12-7 7-methyl-3,3-diphenylindolin-2-one 
• 861011-50-9 N-cyclohexyl-N'-(2-methyl-4,6-dinitro-phenyl)-oxalamide 
• 861012-04-6 N-cyclohexyl-N'-(2-methyl-6-nitro-phenyl)-oxalamide 
• 861012-06-8 N-cyclohexyl-N'-(2-methyl-4-nitro-phenyl)-oxalamide 
• 7477-94-3 2-methyl-4,6-dinitroaniline 

Relevant articles and documents

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be simply and efficiently prepared via a microwave-assisted continuous operation process. Among the compounds synthesised, compound 6–31 showed noteworthy potency against SGC-7901, A549 and HeLa cell lines. In mechanism studies, compound 6–31 inhibited tubulin polymerisation and disorganised microtubule in SGC-7901 cells by binding to tubulin. Moreover, compound 6–31 arrested SGC-7901cells in G2/M phase. This study provided a new perspective for development of antitumor agents that target tubulin.

Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors

A new series of 5-fluoro-3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo- pentanoic acid, 7a-c, 3-[(4-substitutedphenylaminooxalyl)- amino]-4-oxo-5-(2,3, 5,6-tetrafluoro-phenoxy)-pentanoic acid, 7d-h and 5-(2,6-difluoro-phenoxy)-3- [(substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, 7i-p have been synthesized from N-(substituted-phenyl)- oxalamic acid, 1 and their activities have been evaluated in vitro. Compounds 7b,c and k show low micromolar inhibitory activity against caspase-3.

Ligand design for heterobimetallic single-chain magnets: Synthesis, crystal structures, and magnetic properties of MIICuII (M = Mn, Co) chains with sterically hindered methyl-substituted phenyloxamate bridging ligands

Two new series of neutral oxamato-bridged heterobimetallic chains of general formula [MCu(Lx)2]· mDMSO (m = 0-4) (L 1 = N-2-methyl-phenyloxamate, M = Mn (1a) and Co (1b) ; L2 = N-2,6-dimethylphenyloxamate, M = M