53171-39-4Relevant articles and documents
DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES
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Page/Page column 58, (2012/04/04)
The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
FUSED HETEROCYCLIC COMPOUND AND USE THEREOF
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Page/Page column 363, (2008/06/13)
The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.
Selective ammonolysis and aminolysis of dimethyl succinate. Synthesis of optically active N-alkylsuccinimides
Puertas, Susana,Rebolledo, Francisca,Gotor, Vicente
, p. 1495 - 1502 (2007/10/02)
Candida antarctica lipase catalyzes the selective monoammonolysis and aminolysis of dimethyl succinate with ammonia and aliphatic amines, respectively, in dioxane as solvent. This enzyme shows a high enantioselectivity when racemic amines are used. Optically active amidoesters are also obtained in the reaction of dimethyl succinate with racemic α-methylalkylamines in hexane as solvent. In this medium, the enzyme catalyzes the formation of N-alkylsuccinimides or optically active N-alkyl-α-methylsuccinimides from dimethyl succinate or α-methylsuccinate and amines.