53173-90-3

Basic information

• Product Name: methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate
• Synonyms: methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate
• CAS NO: 53173-90-3
• Molecular Weight: 247.078
• Mol File: 53173-90-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate(53173-90-3)
• EPA Substance Registry System: methyl 3-chloro-3-(4-chlorophenyl)-2-oxopropanoate(53173-90-3)

Safety Data

• Hazardous Substances Data: 53173-90-3(Hazardous Substances Data)

Upstream product

• 116-54-1 dichloroacetic acid methyl ester 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 6091-44-7 piperidine hydrochloride 
• 1048647-87-5 methyl 1-(4-chlorobutyl)-2-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate 

Relevant articles and documents

Intermolecular cyclocondensation of arylchloropyruvates in the synthesis of 2,3-dihydrofuran-3,5-dicarboxylic acid derivatives

Methyl arylchloropyruvates undergo intermolecular self-condensation in the presence of a catalytic amount of a base under high-temperature conditions (~250°C) with the formation of 3,4-diaryl-2-oxo-2,3-dihydrofuran-3,5-dicarboxylic acid derivatives.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes with metal halides and silica-gel-supported metal halides. Synthesis of substituted but-3-en-4-olides.

Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes 1 with transition metal halides (copper(II) chloride, copper (II) bromide, zinc bromide, cobalt chloride and ferric chloride) and silica-gel-supported metal halides gave methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates 5, 6 and methyl 3-aryl-3-halo-2-oxopropanoates 2, 3.The reaction of 1 in chlorobenzene under reflux with silica-gel-supported copper (II) halides gave but-3-en-4-olides 4.Key Words: methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates; methyl 3-aryl-3-halo-2-oxopropanoates; but-3-en-4-olides.