532-16-1

Basic information

• Product Name: 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one
• Synonyms: 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one;(E,E)-7-((3,7,11-Trimethyl-2,6,10-dodecatrienyl)oxy)-2H-1-benzopyran-2-one
• CAS NO: 532-16-1
• Molecular Formula: C24H30O3
• Molecular Weight: 366.49
• Mol File: 532-16-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 512.6°Cat760mmHg
• Flash Point: 222.3°C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 1.27E-10mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one(532-16-1)
• EPA Substance Registry System: 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one(532-16-1)

Safety Data

• Hazardous Substances Data: 532-16-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H30O3/c1-18(2)7-5-8-19(3)9-6-10-20(4)15-16-26-22-13-11-21-12-14-24(25)27-23(21)17-22/h7,9,11-15,17H,5-6,8,10,16H2,1-4H3/b19-9+,20-15+

Upstream product

• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 24163-93-7 farnesyl bromide 

Relevant articles and documents

Synthesis of prenyloxy coumarin analogues and evaluation of their antioxidant, lipoxygenase (LOX) inhibitory and cytotoxic activity

Umbelliferone, 4-methyl-umbelliferone and their farnesyloxy and geranyloxy analogues were synthesized and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity as well as their cytotoxicity against human neuroblastoma cell line SK-N-SH and human hepatoma cell line HepG2. Auraptene (3), followed by 4-methyl-auraptene (4) exhibit modest cytotoxity against the HepG2 cell line. The novel coumarin 6 combines a satisfactory lipoxygenase inhibitory activity with potent cytotoxicity against SK-N-SH cells, but not against HepG2 cells, thus it could be considered as a lead compound for the development of novel therapeutic agents against neuroblastoma.