5325-15-5

Basic information

• Product Name: 2-chloro-1-(10H-phenothiazin-2-yl)ethanone
• Synonyms: 2-Chloro-1-(10H-phenothiazin-2-yl)ethanone; 2-Chloroacetylphenothiazine
• CAS NO: 5325-15-5
• Molecular Formula: C₁₄H₁₀ClNOS
• Molecular Weight: 275.7533
• Mol File: 5325-15-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 493.4°C at 760 mmHg
• Flash Point: 252.2°C
• Density: 1.348g/cm³
• Vapor Pressure: 7.05E-10mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 2-chloro-1-(10H-phenothiazin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(10H-phenothiazin-2-yl)ethanone(5325-15-5)
• EPA Substance Registry System: 2-chloro-1-(10H-phenothiazin-2-yl)ethanone(5325-15-5)

Safety Data

• Hazardous Substances Data: 5325-15-5(Hazardous Substances Data)

Upstream product

• 1628-29-1 10-acetyl-10H-phenothiazine 
• 79-04-9 chloroacetyl chloride 
• 5325-18-8 10-acetyl-2-(chloroacetyl)-phenothiazine 
• 93989-34-5 2-bromoacetyl-10-chloroacetyl-10H-phenothiazine 
• 92794-67-7 2,10-bis-chloroacetyl-10H-phenothiazine 

Downstream Products

• 58754-58-8 2-acetoxy-benzoic acid 2-oxo-2-(10-phenoxyacetyl-10H-phenothiazin-2-yl)-ethyl ester 
• 58754-57-7 2-hydroxy-benzoic acid 2-oxo-2-(10-phenoxyacetyl-10H-phenothiazin-2-yl)-ethyl ester 
• 58754-72-6 2-chloroacetyl-10-phenoxyacetyl-10H-phenothiazine 
• 5325-18-8 10-acetyl-2-(chloroacetyl)-phenothiazine 
• 10553-99-8 2-(N.N-Dibutyl-aminoacetyl)-phenthiazin 
• 10554-00-4 2-(N.N-Dipropyl-aminoacetyl)-phenthiazin 
• 58754-61-3 4-acetylamino-benzoic acid 2-oxo-2-(10H-phenothiazin-2-yl)-ethyl ester 
• 58754-59-9 2-acetoxy-benzoic acid 2-oxo-2-(10H-phenothiazin-2-yl)-ethyl ester 
• 58754-62-4 2-(4-chloro-benzoyloxy)-1-(10H-phenothiazin-2-yl)-ethanone 
• 58754-60-2 2-hydroxy-benzoic acid 2-oxo-2-(10H-phenothiazin-2-yl)-ethyl ester 

Relevant articles and documents

Derivatives of heterocycles with 5 members, their preparation and their use as medicaments

The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48 R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.