53253-67-1

Basic information

• Product Name: diethyl (3-cyanopropyl)phosphonate
• CAS NO: 53253-67-1
• Molecular Formula: C₈H₁₆NO₃P
• Molecular Weight: 205.1913
• Mol File: 53253-67-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 323.5°C at 760 mmHg
• Flash Point: 149.4°C
• Density: 1.075g/cm³
• Vapor Pressure: 0.000262mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: diethyl (3-cyanopropyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (3-cyanopropyl)phosphonate(53253-67-1)
• EPA Substance Registry System: diethyl (3-cyanopropyl)phosphonate(53253-67-1)

Safety Data

• Hazardous Substances Data: 53253-67-1(Hazardous Substances Data)

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 2303-76-6 sodium diethyl phosphite 
• 3167-63-3 diethyl chloromethylphosphonate 
• 107-13-1 acrylonitrile 
• 66197-72-6 diethyl (bromomethyl)phosphonate 
• 10419-77-9 diethyl iodomethanephosphonate 
• 38066-16-9 diethyl [(phenylthio)methyl]phosphonate 
• 122-52-1 triethyl phosphite 
• 5332-06-9 4-bromobutanenitrile 

Relevant articles and documents

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound. Specifically, the preparation method comprises the following step: in an organic solvent, in the presence of a protective gasand under the action of a catalyst, carrying out a reduction reaction as shown in the specification on olefin as shown in a formula I, a cyanation reagent and water, wherein the alkyl nitrile compound 1 is a compound II and/or a compound III. The preparation method provided by the invention is mild in condition, can realize hydrocyanation of olefin more safely and efficiently, and has good substrate universality and functional group compatibility.

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In recent years phosphonylated ketones were considered as valuable intermediates in organic synthesis. In the present work we studied the reaction of cyanoalkylphosphonates 1 with organozinc compounds which led after hydrolysis to the corresponding phosph

Studies on the Free Radical Carbon-Carbon Bond Formation in the Reaction of α-Phosphoryl Sulfides and Selenides with Alkenes

α-Mono- and α,α-disubstituted α-phosphoryl radicals 9 were generated from the easy accessible α-phosphoryl sulfides 4, 5 and α-phosphoryl selenides 11, 12 and reacted with the electron rich alkenes 6 under the reductive (n-Bu3SnH/AIBN) conditions to give the functionalized phosphonates 7 in 32+68percent yield.Two fragmentation processes of the phosphonate α-alkoxy alkyl radicals are also described. - Key words: α-phosphoryl sulfides, α-phosphoryl selenides, intermolecular radical reaction, radical fragmentation, phosphonates, tri-n-butyltin hydride, α,α'-azaisobutyronitrile