53277-47-7

Basic information

• Product Name: Methyl 4-chloro-6-methylnicotinate
• Synonyms: Methyl 4-chloro-6-methylnicotinate;2-Chloro-6-methyl-3-pyridinecarboxylic acid methyl ester;Methyl 2-chloro-6-methylnicotinate;3-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, Methyl ester;Methyl 2-chloro-6-methylpyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methylpyridine;METHYL6-METHYL-2-CHLOROPYRIDINE-3-CARBOXYLATE
• CAS NO: 53277-47-7
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.609
• EINECS: -0
• Mol File: 53277-47-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 27-28℃
• Boiling Point: 253℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.247
• Vapor Pressure: 0.0335mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.43±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-chloro-6-methylnicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-chloro-6-methylnicotinate(53277-47-7)
• EPA Substance Registry System: Methyl 4-chloro-6-methylnicotinate(53277-47-7)

Safety Data

• Hazardous Substances Data: 53277-47-7(Hazardous Substances Data)

Usage

General Description

Methyl 4-chloro-6-methylnicotinate is a chemical compound with the molecular formula C9H9ClNO2. It is a derivative of nicotinic acid and is commonly used in the synthesis of pharmaceuticals and agrochemicals. Methyl 4-chloro-6-methylnicotinate is a white to off-white crystalline powder with a slightly bitter taste and is slightly soluble in water. It is often used as an intermediate in the production of various drugs and is known for its anti-inflammatory and analgesic properties. Additionally, it is commonly utilized as a flavoring agent in the food and beverage industry. It is important to handle this chemical with caution as it may be harmful if swallowed, inhaled, or comes into contact with the skin.

InChI:InChI=1/C8H8ClNO2/c1-5-3-7(9)6(4-10-5)8(11)12-2/h3-4H,1-2H3

Upstream product

• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 79-37-8 oxalyl dichloride 
• 74-88-4 methyl iodide 
• 39853-81-1 2-chloro-6-methyl-nicotinic acid chloride 

Downstream Products

• 232602-13-0 2-benzyl-6-methyl-nicotinic acid methyl ester 
• 1312697-17-8 5-[5-(3,5-Bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-indolizine-8-carboxylic acid [(2,2,2-trifluoroethylcarbamoyl)methyl]-amide 
• 1312697-60-1 5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-indolizine-8-carboxylic acid 
• 1312697-63-4 6-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloro-nicotinic acid methyl ester 
• 1312697-64-5 6-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-prop-1-ynyl-nicotinic acid methyl ester 
• 1312697-65-6 5-[5-(3,5-bis-trifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-indolizine-8-carboxylic acid methyl ester 
• 1312697-77-0 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid 
• 1312697-78-1 2-chloro-6-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-nicotinic acid methyl ester 
• 1312697-79-2 6-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-(3-hydroxy-but-1-ynyl)-nicotinic acid methyl ester 
• 1312697-80-5 6-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-(3-methanesulfonyloxy-but-1-ynyl)-nicotinic acid methyl ester 
• 1312697-81-6 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid methyl ester 
• 689259-06-1 (2-chloro-6-methylpyridin-3-yl)methanol 
• 1375637-35-6 (R)-[5-(2-methoxy-6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-[6-(piperidin-3-yloxy)-pyrazin-2-yl]-amine 
• 1263286-09-4 methyl 2-chloro-6-formylpyridine-3-carboxylate 

Relevant articles and documents

BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE

Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

2-HYDROXYMETHYL-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 2-hydroxymethyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.