532987-11-4

Basic information

• Product Name: Methyl 2-aMino-2-(3-chlorophenyl)acetate
• Synonyms: Methyl 2-aMino-2-(3-chlorophenyl)acetate;Amino-(3-chloro-phenyl)-acetic acid methyl ester;Clopidogrel Impurity 9;DL-3-Chlorophenylglycine methyl ester
• CAS NO: 532987-11-4
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.6342
• Mol File: 532987-11-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 268.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.258±0.06 g/cm3(Predicted)
• PKA: 6.41±0.10(Predicted)
• CAS DataBase Reference: Methyl 2-aMino-2-(3-chlorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-aMino-2-(3-chlorophenyl)acetate(532987-11-4)
• EPA Substance Registry System: Methyl 2-aMino-2-(3-chlorophenyl)acetate(532987-11-4)

Safety Data

• Hazardous Substances Data: 532987-11-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 587-04-2 m-Chlorobenzaldehyde 
• 7292-71-9 2-(3-chlorophenyl)glycine 

Downstream Products

• 1227294-02-1 (2S,3S,3aS,9bS)-3-ethyl-2-methyl-2-(3-chlorophenyl)-1,2,3,3a,4,9b-hexahydrochromeno[4,3-b]pyrrole-2,3-dicarboxylate 
• 7292-71-9 2-(3-chlorophenyl)glycine 
• 1423136-82-6 methyl 4-benzoyl-2-(3-chlorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 1423136-83-7 methyl 4-benzoyl-2-(3-chlorophenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 25871-69-6 1,3,5-tribenzoylbenzene 
• 1322877-79-1 trimethyl (2S,3S,4R,5S)-2-(3-chlorophenyl)-5-(4-nitrophenyl)pyrrolidine-2,3,4-tricarboxylate 
• 532986-41-7 N-[1-(3-chlorophenyl)-2-hydroxyethyl]octanamide 

Relevant articles and documents

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF

Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 to R8 and n are defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.